Pancreatic juice is alkaline in nature due to the high concentration of bicarbonate ions. Bicarbonate is useful in neutralizing the acidic gastric acid, allowing for effective enzymic action.
Pancreatic juice secretion is regulated by the hormonessecretin and cholecystokinin, which is produced by the walls of the duodenum upon detection of acid food, proteins, fats and vitamins. Pancreatic secretion consists of an aqueous bicarbonate component from the duct cells and enzymatic component from the acinar cells. A clear alkaline secretion of the pancreas containing enzymes that aid in the digestion of proteins, carbohydrates, and fats.