Pancreatic serous cystadenoma

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Pancreatic serous cystadenoma
Other namesSerous cystadenoma of the pancreas, serous microcystic adenoma
Pancreatic serous cystadenoma - intermed mag.jpg
Micrograph showing a pancreatic serous cystadenoma. H&E stain.
SpecialtyGeneral surgery, oncology

Pancreatic serous cystadenoma is a benign tumour of pancreas. It is usually found in the tail of the pancreas,[1] and may be associated with von Hippel-Lindau syndrome.[2]

In contrast to some of the other cyst-forming tumors of the pancreas (such as the intraductal papillary mucinous neoplasm and the mucinous cystic neoplasm), serous cystic neoplasms are almost always entirely benign. There are some exceptions; rare case reports have described isolated malignant serous cystadenocarcinomas.[3] In addition, serous cystic neoplasms slowly grow, and if they grow large enough they can press on adjacent organs and cause symptoms.


Pathologists classify serous cystic neoplasms into two broad groups. Those that are benign, that have not spread to other organs, are designated "serous cystadenoma".[4] Serous cystadenomas can be further sub-typed into microcystic, oligocystic (or macrocystic), solid, mixed serous-endocrine neoplasm, and VHL-associated serous cystic neoplasm. This latter classification scheme is useful because it highlights the range of appearances and the clinical associations of these neoplasms. Serous cystic neoplasms that have spread ("metastasized") to another organ are considered malignant and are designated "serous cystadenocarcinoma".



These lesions rarely require surgery unless they are symptomatic or the diagnosis is in question. Since these lesions do not have malignant potential, long-term observation is unnecessary. Surgery can include the removal of the head of the pancreas (a pancreaticoduodenectomy), removal of the body and tail of the pancreas (a distal pancreatectomy), or rarely removal of the entire pancreas (a total pancreatectomy).[5] In selected cases the surgery can be performed using minimally invasive techniques such as laparoscopy.[6]

See also[edit]


  1. ^ Colonna, J.; Plaza, JA.; Frankel, WL.; Yearsley, M.; Bloomston, M.; Marsh, WL. (2008). "Serous cystadenoma of the pancreas: clinical and pathological features in 33 patients". Pancreatology. 8 (2): 135–41. doi:10.1159/000123606. PMID 18382099.
  2. ^ Eras, M.; Yenigun, M.; Acar, C.; Kumbasar, B.; Sar, F.; Bilge, T. "Pancreatic involvement in Von Hippel-Lindau disease". Indian J Cancer. 41 (4): 159–61. PMID 15659868.
  3. ^ Galanis C, Zamani A, Cameron JL, et al. (July 2007). "Resected serous cystic neoplasms of the pancreas: a review of 158 patients with recommendations for treatment". J. Gastrointest. Surg. 11 (7): 820–6. doi:10.1007/s11605-007-0157-4. PMID 17440789.
  4. ^ "Pathology of Neoplasms of the Pancreas". Johns Hopkins University. Retrieved 25 April 2010.
  5. ^ "Pancreatic Surgery". Johns Hopkins University. Retrieved 25 April 2010.
  6. ^ "Laproscopic Pancreatic Surgery". Johns Hopkins University. Retrieved 25 April 2010.

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External resources