Panikos Krystallis is a former football forward. He was born in Limassol, Cyprus, in 1942.
Krystallis started his football career in AEL Limassol in the late 1950s but soon joined cross-town rivals Apollon Limassol where he had his best years as a striker. He led the league in scoring during the 1960–61 season.
He spent two years in the Greek A Ethniki Catigoria (1962 and 1963) playing for AEK Athens but returned to Cyprus in 1963.
During his career, he was capped 19 times by the Cyprus national football team scoring 4 goals.
After his playing career was over, Krystallis coached various clubs including AEL Limassol, Apollon Limassol, Evagoras and the Cyprus national football team.