Paolo Zamboni

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Paolo Zamboni
Paolo Zamboni image.jpg
Paolo Zamboni
Born(1957-03-25)25 March 1957
AwardsISNVD Gold Medal
Scientific career
FieldsVascular surgery
InstitutionsFerrara, Italy

Paolo Zamboni (born 25 March 1957, Ferrara, Italy) is an Italian doctor who claims to have found in an unblinded preliminary study that in over 90% of the participants with multiple sclerosis there were problems in veins draining their brain, like stenosis or defective valves.[1] He also noticed high level of accumulation of iron deposits in the brain, supposedly due to restricted outflow of blood.[2]

According to Zamboni some symptoms of multiple sclerosis in his own wife as well as 73% of his patients abated after an endovascular procedure to open these veins.[3][4][5]

Zamboni named this condition chronic cerebrospinal venous insufficiency (CCSVI).[6]

The theory was controversial. The National Multiple Sclerosis Society had said that, while "there is not yet enough evidence to conclude that obstruction of veins causes MS," that "[Zamboni's] hypothesis on CCSVI and its corrective treatment is a path that must be more fully explored and one that we are supporting with research funding."[7] Since 2010, there has been more research that disputes the Zamboni theory.[8][9][10]

On November 28, 2017, Zamboni admitted that his treatment is largely ineffective on the basis of "a double-blind randomized controlled trial in which neither patients nor the researchers assessing whether there were improvements post-treatment knew which patients got the actual procedure and which received a sham therapy."[11]


  1. ^ "Sclerosi multipla: la speranza viene da Ferrara? | NN - Notizie dall'Italia e dal Mondo dal 2009". 14 January 2010. Retrieved 7 September 2013.
  2. ^ Singh AV, Zamboni P (December 2009). "Anomalous venous blood flow and iron deposition in multiple sclerosis". J. Cereb. Blood Flow Metab. 29 (12): 1867–78. doi:10.1038/jcbfm.2009.180. PMID 19724286.
  3. ^ Picard, André; Favaro, Avis (20 November 2009). "Researcher's labour of love leads to MS breakthrough". The Globe and Mail. Toronto.
  4. ^ "W5: A whole new approach to MS | CTV News". Retrieved 7 September 2013.
  5. ^ [1] Archived January 23, 2010, at the Wayback Machine
  6. ^ "The Liberation Treatment: A whole new approach to MS" (FLV, Web page). CTV Television Network, W5. 2009. Retrieved 2009-12-10.
  7. ^ "CCSVI and MS FAQ". National Multiple Sclerosis Society. Archived from the original on 22 February 2014. Retrieved 8 February 2014.
  8. ^ "Massive study disputes Zamboni theory of multiple sclerosis". The Globe and Mail. 10 August 2010.
  9. ^ Traboulsee AL. (2013). "Prevalence of extracranial venous narrowing on catheter venography in people with multiple sclerosis, their siblings, and unrelated healthy controls: a blinded, case-control study" (PDF). The Lancet. 383 (9912): 138–145. doi:10.1016/S0140-6736(13)61747-X. PMID 24119384. Archived from the original (pdf) on 2013-10-17. Retrieved 2013-10-17.
  10. ^ Crowe, Kelly. "'From bold idea to scientific quackery': UBC study claims to debunk controversial MS treatment | CBC News". CBC. Retrieved 17 January 2019.
  11. ^ Branswell H. Scientist concedes his controversial MS therapy, once a source of great hope, is ‘largely ineffective’ StatNews:Health. November 28, 2017

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