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For the French opera singer, see Lucinde Paradol.
IUPAC name
Other names
27113-22-0 YesY
ChemSpider 85173 N
EC number 248-228-1
Jmol-3D images Image
KEGG C10482 N
MeSH C421614
PubChem 94378
Molar mass 278.39 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Paradol is the active flavor constituent of the seeds of Guinea pepper (Aframomum melegueta). The seed is also known as Grains of paradise. Paradol has been found to have antioxidative and antitumor promoting effects.[1]

It is used in flavors as an essential oil to give spiciness.

The term "Paradol" has also passed into the language as a handy nonsense term used when describing imaginary substances. This likely derives from The Five Orange Pips, the fifth of the Sherlock Holmes stories by Sir Arthur Conan Doyle. In it, as in a number of other Holmes stories, Dr. Watson drops cryptic references to various cases he was involved in with Holmes which have never been published as stories. He observes that in 1887, the year in which the current story took place, Holmes also solved The Adventure of The Paradol Chamber, though he gives no clue as to what a "Paradol Chamber" might be.

John Dickson Carr wrote a brief script entitled The Paradol Chamber that concerned missing government papers. There "Paradol" was the name of a French diplomat. On May 21, 1945 Mutual Radio debuted an episode of its series The Adventures of Sherlock Holmes (for which Carr was a scenarist) entitled The Paradol Chamber. In it Watson is nearly duped into investing in a phony teleportation device by this name; "Paradol" is the imaginary substance said to be necessary to accomplish the instantaneous transportation of matter. In the 1938 film The Amazing Dr. Clitterhouse Edward G. Robinson plays a physician who commits several murders using an imaginary drug called Sodium Paradol.

See also[edit]


  1. ^ Chung WY, Jung YJ, Surh YJ, Lee SS, Park KK (2001). "Antioxidative and antitumor promoting effects of [6]-paradol and its homologs". Mutat. Res. 496 (1-2): 199–206. doi:10.1016/s1383-5718(01)00221-2. PMID 11551496.