Paramethadione

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Paramethadione
Paramethadione.svg
Systematic (IUPAC) name
(RS)-5-ethyl-3,5-dimethyl-oxazolidine-2,4-dione
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
Pregnancy
category
  • US: D (Evidence of risk)
Pharmacokinetic data
Protein binding Not significant
Identifiers
CAS Number 115-67-3
ATC code N03AC01 (WHO)
PubChem CID 8280
IUPHAR/BPS 7261
DrugBank DB00617 YesY
ChemSpider 7979 YesY
UNII Z615FRW64N YesY
KEGG D00495 YesY
ChEMBL CHEMBL1100 YesY
Chemical data
Formula C7H11NO3
Molar mass 157.167 g/mol
Chirality Racemic mixture
  (verify)

Paramethadione is an anticonvulsant in the oxazolidinedione class. It is associated with fetal trimethadione syndrome, which is also known as paramethadione syndrome.[1]

Chemistry[edit]

Paramethadione, 5-ethyl-3,5-dimethyloxazolidine-2,4-dione, differs from trimethadione only in the substitution of one methyl group with an ethyl group. It is synthesized in a completely analogous manner, except that it comes from 2-hydroxy-2-methylbutyric acid instead of 2-hydroxyisobutyric acid.

References[edit]

External links[edit]

  • Hoffman, D; Chun A (1975). "Paramethadione and metabolite serum levels in humans after a single oral paramethadione dose". J Pharm Sci 64 (10): 1702–1703. doi:10.1002/jps.2600641027. PMID 1185541.