Paraoxon

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Paraoxon
Paraoxon.svg
Paraoxon-3D-balls.png
Clinical data
ATC code
Legal status
Legal status
  • In general: uncontrolled
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.005.657 Edit this at Wikidata
Chemical and physical data
Formula C10H14NO6P
Molar mass 275.195 g/mol
3D model (JSmol)
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Paraoxon is a parasympathomimetic which acts as an acetylcholinesterase inhibitor. It is an organophosphate oxon, and the active metabolite of the insecticide parathion. It is also used as an ophthalmological drug against glaucoma. Paraoxon is one of the most potent acetylcholinesterase-inhibiting insecticides available, around 70% as potent as the nerve agent sarin, and so is now rarely used as an insecticide due to the risk of poisoning to humans and other animals. Paraoxon has been used by scientists to study acute and chronic effects of organophosphate intoxication.[1][2] It is easily absorbed through skin, and was used as an assassination weapon by the apartheid-era South African chemical weapons program Project Coast.[3]

References[edit]

  1. ^ Deshpande, Laxmikant S.; Carter, Dawn S.; Phillips, Kristin F.; Blair, Robert E.; DeLorenzo, Robert J. (2014-09-01). "Development of status epilepticus, sustained calcium elevations and neuronal injury in a rat survival model of lethal paraoxon intoxication". Neurotoxicology. 44: 17–26. doi:10.1016/j.neuro.2014.04.006. ISSN 1872-9711. PMC 4176600Freely accessible. PMID 24785379. 
  2. ^ Deshpande, Laxmikant S.; Phillips, Kristin; Huang, Beverly; DeLorenzo, Robert J. (2014-09-01). "Chronic behavioral and cognitive deficits in a rat survival model of paraoxon toxicity". Neurotoxicology. 44: 352–357. doi:10.1016/j.neuro.2014.08.008. ISSN 1872-9711. PMC 4175062Freely accessible. PMID 25172410. 
  3. ^ NTI Country Overviews:South Africa:Chemical Capabilities:Paraoxon Archived 2008-07-08 at the Wayback Machine.