Parcheesi is typically played with two dice, four pieces per player and a with a track around the outside, four corner spaces and four home paths leading to a central end space. The most popular Parcheesi boards in America have 68 spaces around the edge of the board, 12 of which are darkened safe spaces. Each corner of the board contains one player's nest, or .
- Each player positions their four single colored pieces in their respective starting nest.
- Each player rolls a single die to determine player order. The player with the lowest roll goes first.
- The order of players' turns moves to the next player on the current player's left.
- Pieces move from the nest to the colored starting space to the left of the nest, per rules in the following section.
A player rolls the dice and must use the top die pip values shown to move their pieces around the board in one of the following ways:
- Only pieces not in the nest may move forward on the board.
- Pieces may only leave the nest with a roll of a five on a single die or the sum of the dice. A double five can be used to move two pieces from the nest simultaneously.
- In the case of a non-doubles roll, a player may move one or two pieces, either one piece by each of the numbers on the two dice or one piece by the total. If no move is possible, the turn is forfeited.
- When moving a single piece the total of two dice the turn is taken in increments, allowing pieces to be captured along the way. For example, if a double two is rolled and an opponent's piece lies on a cream space two spaces in front of the piece you wish to move the full four, you would move the piece two, and then two again, allowing the opponent's piece to be captured. 
- All die rolls must be taken and may not be voluntarily forfeited by a player.
- If either of two rolls must be forfeited, the player must forfeit the lower number.
- All die moves must be taken before the application of any extra rewards for sending an opponent to their nest or moving a piece to its home position.
- With a roll of doubles, the player makes four moves, one for each of the numbers on top of the two dice and one for each of the numbers on the bottoms. The player may distribute these four moves among one, two, three, or four pieces. Note that the sum of numbers on the opposite sides of a die is always seven, so with doubles, there are a total of fourteen spaces to move. This can only be done if all four pieces are out of the nest.
- When the player rolls doubles, the player rolls again after moving. 
- When a piece ends its move on the same space as an opponent's piece, the opponent's piece is sent back to its nest.
- A piece may not be placed on a safe space (generally colored light blue) if it is occupied by an opponent's piece. The exception is the safe space used when a piece leaves its nest — a single piece occupying such a safe space is sent back to its nest when an opponent's piece leaves the nest and occupies the space.
- A blockade is formed when two pieces of a single player occupy the same space. No piece of any player may move through a blockade, including pieces of the blockade owner. Blockade pieces may not be moved forward together with the roll of a double . Another player may brake the blockade with the roll of a doble one. Another player's piece cannot land in a space occupied by a blockade, even to leave its nest. Local rules may limit the number of turns that a blockade can stay in place.
- A piece is not required to enter the home row and can pass the row and start another circuit of the board voluntarily or as the result of requirement of the use of the total die roll.
- A turn ends when the next player rolls the dice with the consent of the current player. Any rewards not taken are lost.
Rewards of extra moves
- The reward for sending an opponent's piece to the nest is a free move of twenty spaces that may not be split between pieces.
- The reward for landing a piece in the home space is a free move of ten spaces that may not be split between pieces.
Winning the game
- Moving all four pieces to the home position wins the game.
- Pieces may only be moved to the home position with an exact application of the total roll, the value on a single die, or the complete application of a reward.
In popular culture
- Slang term (meaning unknown) appearing in the 1917 book Parnassus on Wheels by Christopher Morley:
"I was going to buy a Ford, anyway," I said, "and it looks to me as though this parcheesi of yours would be cheaper to run than any flivver that ever came out of Detroit."
The game is referenced in the song 'Do You Want To Play Games' from Big-The Musical, by Maltby & Shire.
- In the 1984 film Ghostbusters Rick Moranis’ character Louis Tully asks his party guests if they wish to play the game parcheesi before being chased out of the building by a Terror Dog.
- In Shrek 2, when Shrek and Fiona come back from the honeymoon, they find their house in a mess with a Parcheesi board next to its open box.
- In Moonrise Kingdom by Wes Anderson in one scene, the three children of Mr. and Mrs. Bishop are seen playing Parcheesi in the floor of the living room while their daughter has run away.
- In the 1981 film 'On Golden Pond' they are seen playing parcheesi at the camp on the lake.
- In the 2007 film The Heartbreak Kid, the character Martin-played by Danny McBride yells: "Miranda...we're getting ready to play Parcheesi...please come upstairs" to Miranda-played by Michelle Monaghan.
- In the 2010 episode of Futurama titled In-A-Gadda-Da-Leela, the character Dr. Zoidberg suggests, "Maybe a Parcheesi tournament."
- "Directions for Playing Parcheesi" (PDF). Parker Brothers Games Ltd. Retrieved 5 November 2014.
- Mohr, Merilyn Simonds (1997). The New Games Treasury. Houghton Mifflin Company. p. 69. ISBN 1-57630-058-7.
To decide who goes first, players take turns throwing one die. The person with the lowest number begins, then play continues clockwise around the board.
- "Parcheesi instructions, 2001" (PDF). Milton-Bradley/Hasbro. Retrieved 31 December 2016.
- "Transcript:In-A-Gadda-Da-Leela - The Infosphere, the Futurama Wiki". theinfosphere.org. Retrieved 2020-05-21.