Park Royal & Twyford Abbey was intended to serve the recently opened Royal Agricultural Society showgrounds at Park Royal; however, despite the proximity of the station (and another to the east on what is now the Central line), the showgrounds were not successful and closed after only a few years. The second part of the station's name was adopted from the nearby Twyford Abbey.
On 6 July 1931, a new Park Royal station was built for the extension of Piccadilly line services to South Harrow. It is located approximately one-third of a mile to the south to provide access from the A40 (Western Avenue), constructed in the 1920s. Nothing of the old station remains.
Unusually, whilst the site of Park Royal & Twyford Abbey is on the route of the modern Piccadilly line, it was never served by Piccadilly line trains, as they did not begin to operate to South Harrow until July 1932, a year after the station closed.