Paromamine 6'-oxidase

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Paromamine 6'-oxidase
Identifiers
EC number 1.1.3.43
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Paromamine 6'-oxidase (EC 1.1.3.43, btrQ (gene), neoG (gene), kanI (gene), tacB (gene)) is an enzyme with systematic name paromamine:oxygen 6'-oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction

paromamine + O2 6'-dehydroparomamine + H2O2

This enzymes participates in biosynthesis of several aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin.

References[edit]

  1. ^ Huang, F.; Spiteller, D.; Koorbanally, N.A.; Li, Y.; Llewellyn, N.M.; Spencer, J.B. (2007). "Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin". ChemBioChem. 8: 283–288. doi:10.1002/cbic.200600371. PMID 17206729. 
  2. ^ Yu, Y.; Hou, X.; Ni, X.; Xia, H. (2008). "Biosynthesis of 3′-deoxy-carbamoylkanamycin C in a Streptomyces tenebrarius mutant strain by tacB gene disruption". J. Antibiot. (Tokyo). 61 (2): 63–69. doi:10.1038/ja.2008.111. PMID 18408324. 
  3. ^ Clausnitzer, D.; Piepersberg, W.; Wehmeier, U.F. (2011). "The oxidoreductases LivQ and NeoQ are responsible for the different 6′-modifications in the aminoglycosides lividomycin and neomycin". J. Appl. Microbiol. 111: 642–651. doi:10.1111/j.1365-2672.2011.05082.x. PMID 21689223. 

External links[edit]