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Paroxysmal hypertension is episodic and volatile high blood pressure, which may be due to stress of any sort, or from a pheochromocytoma, a type of tumor involving the adrenal medulla. Patients with paroxysmal hypertension who test negative for pheochromocytoma are said to be suffering from a clinical entity called "pseudopheochromocytoma." This disorder is due to episodic dopamine discharge and has been observed predominantly in hypertensive women, that had episodes that shared similar characteristics of pheochromocytoma but testing proved negative and had ruled out the tumor. In patients with pseudopheochromocytoma dopamine was found to be significantly increased post-paroxysm. The paroxysm is said to be similar to the hypertensive episodes described by Page. These episodes commonly occur after diencephalic stimulation. Therefore, pseudopheochromocytoma, shares many characteristics of "Page's syndrome."
Pseudopheochromocytoma, colloquially known as page's syndrome, is caused predominantly by episodic dopamine discharge, stressors including pain or anxiety, or possibly repressed emotions caused by prior emotional trauma and commonly, a repressive way of coping emotionally. Therefore, treatment of pseudopheochromocytoma is aimed at psychological support and intervention with antidepressants, but also treatment with alpha and then beta blockers in resistant cases.
- Kuchel O (1985). "Pseudopheochromocytoma". Hypertension. 7 (1): 151–8. PMID 3980057. doi:10.1161/01.hyp.7.1.151.
- *Kuchel O, Buu NT, Larochelle P, Hamet P, Genest J (1986). "Episodic dopamine discharge in paroxysmal hypertension. Page's syndrome revisited". Archives of Internal Medicine. 146 (7): 1315–20. PMID 3718127. doi:10.1001/archinte.1986.00360190079011.
- *Seck SM, Ka EF, Niang A, Diouf B (2009). "Pseudopheochromocytoma: An uncommon cause of malignant hypertension". Indian Journal of Nephrology. 19 (3): 122–4. PMC . PMID 20436734. doi:10.4103/0971-4065.57111.
- Kuchel O, Buu NT, Larochelle P, Hamet P, Genest J (1986). "Episodic dopamine discharge in paroxysmal hypertension. Page's syndrome revisited". Archives of Internal Medicine. 146 (7): 1315–20. PMID 3718127. doi:10.1001/archinte.1986.00360190079011.
- Seck SM, Ka EF, Niang A, Diouf B (2009). "Pseudopheochromocytoma: An uncommon cause of malignant hypertension". Indian Journal of Nephrology. 19 (3): 122–4. PMC . PMID 20436734. doi:10.4103/0971-4065.57111.
- Mann SJ (2008). "Severe paroxysmal hypertension (pseudopheochromocytoma)". Current Hypertension Reports. 10 (1): 12–8. PMID 18367021. doi:10.1007/s11906-008-0005-2.
- Páll A, Becs G, Erdei A, Sira L, Czifra A, Barna S, Kovács P, Páll D, Pfliegler G, Paragh G, Szabó Z (2014). "Pseudopheochromocytoma induced by anxiolytic withdrawal". European Journal of Medical Research. 19: 53. PMC . PMID 25288254. doi:10.1186/s40001-014-0053-9.
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