From Wikipedia, the free encyclopedia
  (Redirected from Pasha (protein))
Jump to: navigation, search
DGCR8 microprocessor complex subunit
Protein DGCR8 PDB 1x47.png
PDB rendering based on 1x47.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols DGCR8 ; C22orf12; DGCRK6; Gy1; pasha
External IDs OMIM609030 MGI2151114 HomoloGene11223 GeneCards: DGCR8 Gene
RNA expression pattern
PBB GE DGCR8 219811 at tn.png
PBB GE DGCR8 218650 at tn.png
PBB GE DGCR8 64474 g at tn.png
More reference expression data
Species Human Mouse
Entrez 54487 94223
Ensembl ENSG00000128191 ENSMUSG00000022718
UniProt Q8WYQ5 Q9EQM6
RefSeq (mRNA) NM_001190326 NM_033324
RefSeq (protein) NP_001177255 NP_201581
Location (UCSC) Chr 22:
20.08 – 20.11 Mb
Chr 16:
18.25 – 18.29 Mb
PubMed search [1] [2]

The DGCR8 microprocessor complex subunit (DiGeorge syndrome chromosomal [or critical] region 8) is a protein that in humans is encoded by the DGCR8 gene.[1] In other animals, particularly the common model organisms Drosophila melanogaster and Caenorhabditis elegans, the protein is known as Pasha (partner of Drosha).[2] It is a required component of the RNA interference pathway.


DGCR8 is localized to the cell nucleus and is required for microRNA (miRNA) processing. It binds to Drosha, an RNase III enzyme, to form the Microprocessor complex that cleaves a primary transcript known as pri-miRNA to a characteristic stem-loop structure known as a pre-miRNA, which is then further processed to miRNA fragments by the enzyme Dicer. DGCR8 contains an RNA-binding domain and is thought to bind pri-miRNA to stabilize it for processing by Drosha.[3]


  1. ^ "Entrez Gene: DGCR8 DiGeorge syndrome critical region gene 8". 
  2. ^ Denli AM, Tops BB, Plasterk RH, Ketting RF, Hannon GJ (Nov 2004). "Processing of primary microRNAs by the Microprocessor complex". Nature 432 (7014): 231–5. doi:10.1038/nature03049. PMID 15531879. 
  3. ^ Yeom KH, Lee Y, Han J, Suh MR, Kim VN (2006). "Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing". Nucleic Acids Research 34 (16): 4622–9. doi:10.1093/nar/gkl458. PMC 1636349. PMID 16963499. 

Further reading[edit]