DGCR8

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DGCR8 microprocessor complex subunit
Protein DGCR8 PDB 1x47.png
PDB rendering based on 1x47.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols DGCR8 ; C22orf12; DGCRK6; Gy1; pasha
External IDs OMIM609030 MGI2151114 HomoloGene11223 GeneCards: DGCR8 Gene
RNA expression pattern
PBB GE DGCR8 219811 at tn.png
PBB GE DGCR8 218650 at tn.png
PBB GE DGCR8 64474 g at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 54487 94223
Ensembl ENSG00000128191 ENSMUSG00000022718
UniProt Q8WYQ5 Q9EQM6
RefSeq (mRNA) NM_001190326 NM_033324
RefSeq (protein) NP_001177255 NP_201581
Location (UCSC) Chr 22:
20.08 – 20.11 Mb
Chr 16:
18.25 – 18.29 Mb
PubMed search [1] [2]

The DGCR8 microprocessor complex subunit (DiGeorge syndrome chromosomal [or critical] region 8) is a protein that in humans is encoded by the DGCR8 gene.[1] In other animals, particularly the common model organisms Drosophila melanogaster and Caenorhabditis elegans, the protein is known as Pasha (partner of Drosha).[2] It is a required component of the RNA interference pathway.

Function[edit]

DGCR8 is localized to the cell nucleus and is required for microRNA (miRNA) processing. It binds to Drosha, an RNase III enzyme, to form the Microprocessor complex that cleaves a primary transcript known as pri-miRNA to a characteristic stem-loop structure known as a pre-miRNA, which is then further processed to miRNA fragments by the enzyme Dicer. DGCR8 contains an RNA-binding domain and is thought to bind pri-miRNA to stabilize it for processing by Drosha.[3]

References[edit]

  1. ^ "Entrez Gene: DGCR8 DiGeorge syndrome critical region gene 8". 
  2. ^ Denli AM, Tops BB, Plasterk RH, Ketting RF, Hannon GJ (Nov 2004). "Processing of primary microRNAs by the Microprocessor complex". Nature 432 (7014): 231–5. doi:10.1038/nature03049. PMID 15531879. 
  3. ^ Yeom KH, Lee Y, Han J, Suh MR, Kim VN (2006). "Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing". Nucleic Acids Research 34 (16): 4622–9. doi:10.1093/nar/gkl458. PMC 1636349. PMID 16963499. 

Further reading[edit]