Born in Radnor, Pennsylvania, Chambers played collegiate basketball at Philadelphia University. Despite joining the team without a scholarship, he left it as the starting point guard and the team record-holder in assists. He is currently 7th all-time in steals and led the team to four NCAA Division II Sweet 16 appearances and two Elite Eight finishes.
In Chambers' second season at Boston University, he again led the Terriers to a 21-14 overall mark, including a 12-4 mark in conference play. They defeated Stony Brook University at Agganis Arena to win their sixth conference title and clinch an automatic bid into the NCAA Tournament. They received a #16 seed and fell to the #1 seed Kansas Jayhawks in the first round by a score of 72-53. The game marked the Terriers' first appearance in the NCAA tournament since 2002.
Penn State announced Chambers as the 12th head coach in Nittany Lion basketball history in June 2011. He hit the ground running traveling 10,500 miles in his first eight days on the job to visit returning and incoming players and energizing the fan base with his passionate and positive style. He took over a team that returned one starter and just two players with significant playing experience. In his first season, he guided junior guard Tim Frazier to first-team All-Big Ten honors (just the sixth player in program history to earn first team honors) as he produced the second largest scoring improvement in the Big Ten in the past 15 years going from 6.3 ppg as a sophomore to 18.8 ppg as a junior while leading the Big Ten in assists (6.2) and finishing second in scoring and steals (2.4). The Lions posted a 12-20 record and knocked off one ranked opponent (No. 22 Illinois).
Chambers and his wife Courtney have 4 children, Grace, Ryan, Caitlyn, and Patrick Jr.
National champion Postseason invitational champion Conference regular season champion Conference regular season and conference tournament champion Division regular season champion Division regular season and conference tournament champion Conference tournament champion