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Pathrusim were descendants of Mizraim (i.e., Egypt) according to the genealogies in Genesis, who inhabited Pathros (i.e., Upper Egypt).

In Book of Jasher (trans. Moses Samuel c. 1840, ed. J. H. Parry 1887) Chapter 10:23, the Pathrusim and Casluhim intermarried resulting in the Pelishtim, Azathim, Gerarim, Githim, and Ekronim.