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Patient zero may refer to:
- In medical science, the index case or initial patient in the population of an epidemiological investigation
- Gaëtan Dugas (1953–1984), incorrectly considered to be the initial source of AIDS in North America, and the origin of the term "patient zero"
- Patient Zero: A Joe Ledger Novel, by Jonathan Maberry
- "Patient Zero", a song from the album Infected by the metal band HammerFall
- "Patient Zero" (The Outer Limits), a 2001 television episode
- Patient Zero (audio drama), based on the television series Doctor Who
- Patient Zero (film), 2018 fantasy-horror film
- Patient Zero, a demoscene production by Farbrausch
- "Patient Zero", the last part of the video game Trauma Team
- "Patient Zero", Special Zombie in the video game Apocalypse Rising
- Zero Patience, a musical about AIDS
| disambiguation page lists articles associated with the title Patient zero.
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