Patrick Holford is a British author and entrepreneur who endorses a range of vitamin tablets. As an advocate of alternative nutrition and diet methods, he appears regularly on television and radio in the UK and abroad. He has 36 books in print in 29 languages. His business career promotes a wide variety of alternative medical approaches such as orthomolecular medicine, many of which are considered pseudoscientific by mainstream science and medicine.
Holford obtained a BSc in experimental psychology from the University of York in 1979. As a psychology student, he became interested in the biochemistry of mental health problems. His research brought him in contact with Dr Carl Pfeiffer and Dr Abram Hoffer, both of whom claimed success in treating mental illness with nutritional therapy.
In 1984, Holford founded the Institute for Optimum Nutrition (ION). At that institute, he has worked on nutritional approaches to clinical depression, schizophrenia, ADHD and eating disorders. In 1995, the Board of Trustees of ION (of which he was a director) awarded him an Honorary Diploma in Nutritional Therapy.
He retired as Director of ION in 1998 and was awarded ION's Award for Excellence in 2009.
He is the chief executive officer and co-founder (with Professor André Tylee of the Institute of Psychiatry) of the special interest group that developed into Food for the Brain Foundation, a registered charity which has the stated aim of promoting mental health through nutrition. He is also director of the Brain Bio Centre, which specialises in a nutrition-based approach to mental health problems.
Holford is a Fellow of the British Association for Nutritional Therapy (BANT), one of a number of professional bodies that seek to represent nutritional therapists in the UK. He is a Complementary and Natural Healthcare Council (CNHC) registered practitioner. He is also the Patron of the South African Association of Nutritional Therapy and the Irish Association of Nutritional Therapy.
Holford has been the subject of criticism for his promotion of medically dubious techniques and products including hair analysis, his support of the now struck off doctor Andrew Wakefield, and advocating the use of "non-drug alternatives for mental health" for which he has been given an award by the Church of Scientology-backed Citizens Commission on Human Rights.
Holford's claim in The New Optimum Nutrition Bible that "AZT, the first prescribable anti-HIV drug, is potentially harmful, and proving less effective than vitamin C" has been criticised by Ben Goldacre. Goldacre writes that Holford based this conclusion on a non-clinical study where "you tip lots of vitamin C onto HIV-infected cells and measure a few things related to HIV replication". Goldacre notes that the paper does not compare vitamin C to AZT for efficacy. He argues that "Holford was guilty of at least incompetence in claiming that this study demonstrated vitamin C to be a better treatment than AZT." Prof David Colquhoun argues that Holford's "advocacy of vitamin C as better than conventional drugs to treat Aids is truly scary".
"As [Goldacre] well knows, the author of the research – Dr Raxit Jariwalla – wrote to the Guardian (January 20, 2005) the last time Goldacre made this claim, to confirm that my statement is correct on the basis of two [non-clinical] studies on HIV-infected cells. The real crime here is that no full-scale human trials have been funded on vitamin C to follow up Jariwalla's important finding because it is non-patentable and hence not profitable. Goldacre seems unconcerned about the way commercial interests distort scientific research."
Holford is one of the main supporters of the hypothesis that there is a potential link in some susceptible children between the MMR vaccine and the development of autism-like symptoms. This is against the overwhelming  opposition to the hypothesis by members of the scientific community. The Wakefield et al. paper upon which this hypothesis was based has been discredited by the scientific community and 10 of the 12 co-authors have formally retracted the paper. Furthermore, Centers for Disease Control and Prevention, the Institute of Medicine of the National Academy of Sciences, the UK National Health Service and the Cochrane Library review have all concluded that there is no evidence of a link between the MMR vaccine and autism. (See MMR vaccine controversy)
The Cochrane Library's systematic review also concluded that "The design and reporting of safety outcomes in MMR vaccine studies, both pre- and post- marketing, are largely inadequate...." Nonetheless, it noted that the vaccine has prevented diseases that still carry a heavy burden of death and complications, and that the lack of confidence in the vaccine has damaged public health.
Catherine Collins, chief dietician at St George's Hospital, reported that after following Holford's advice to adopt a restricted diet, a young autistic girl participating in one of Holford's experiments suffered dramatic weight loss and sleep problems. Holford dismissed the allegations as "professional jealousy", stating that "This girl hasn't suffered. She's got better and is behaving better. Her parents are delighted with the results. It's only Catherine Collins who is not." Holford claimed that the girl was already a poor sleeper, and that when placed on a less restrictive diet, she was able to regain the weight she had lost.
There has also been an adjudication by the Advertising Standards Authority against Patrick Holford's 100% Health leaflet. "On this point, the ad breached CAP Code clauses 3.1 (Substantiation), 7.1 (Truthfulness), 50.1 (Health & beauty products and therapies – General) and 50.20 (Health & beauty products and therapies – Vitamins, minerals and other food supplements)."  A previous adjudication by the ASA also went against Mr Holford. 
- The Family Nutrition Workbook (1988)
- The Whole Health Manual: Comprehensive Guide to Nutrition and Better Health (1988)
- The Better Pregnancy Diet: The Definitive Guide to Having a Healthy Baby (1993)
- The Optimum Nutrition Bible (1997)
- Say No to Heart Disease (updated 2012)
- Boost Your Immune System (1998)
- Balancing Hormones Naturally (1998)
- 30-Day Fatburner Diet (1999)
- 100% Health (1999)
- Beat Stress and Fatigue (1999)
- Say No to Cancer (1999)
- The Optimum Nutrition Cookbook (1999)
- Improve Your Digestion (2000)
- Say No to Arthritis (2000)
- Supplements for Superhealth (2000)
- Solve Your Skin Problems (2001)
- Six Weeks to Superhealth (2002)
- Optimum Nutrition for the Mind (2002)
- Natural Highs: Chill – 25 Ways to Stay Relaxed and Beat Stress (2003)
- Natural Highs: Energy – 25 Ways to Increase Your Energy (2003)
- The H Factor – Homocysteine – the biggest breakthrough of the century (2003)
- Boost Your Child's Immune System (2003)
- 500 Health and Nutrition Questions Answered (2004)
- New Optimum Nutrition Bible (2004)
- Optimum Nutrition Before, During and After Pregnancy (2004)
- The Alzheimer's Prevention Plan (2005)
- The Holford Low-GL Diet (2005)
- The Holford Low-GL Diet Cookbook (2005)
- Hidden Food Allergies (2005)
- The Holford Diet GL Counter (2006)
- The Holford Low-GL Diet Made Easy (2006)
- Optimum Nutrition For Your Child's Mind (2006)
- Food is Better Medicine Than Drugs (2006)
- Smart Food for Smart Kids (2007)
- New Optimum Nutrition for the Mind (2007)
- The Holford 9-Day Liver Detox (2007)
- Optimum Nutrition Made Easy: How to Achieve Optimum Health (2008)
- Optimum Nutrition For Your Child (2008)
- How to Quit without Feeling S**t: The Fast, Highly Effective Way to End Addiction to Caffeine, Sugar, Cigarettes, Alcohol, Illicit or Prescription Drugs (2008)
- Food Glorious Food: Incredibly Delicious Low-GL Recipes for Friends and Family (2008)
- The Low-GL Diet Bible by Patrick Holford (2009)
- The 10 Secrets of 100% Healthy People (2009)
- The Perfect Pregnancy Cookbook (2010)[needs update]
- 100% Health Survey (2010)
- The Optimum Nutrition Cookbook (2010)
- The Feel Good Factor (2010)
- Say no to Diabetes (2011)
- 10 Secrets of Healthy Ageing (2012)
- 10 Secrets of 100% Health Cookbook (2012)
- Burn Fat Fast (2013)
- The Stress Cure (2015)
- Goldacre, Ben (2008). Bad Science. HarperPerennial. ISBN 000728487X
- Thompson, Damian (2008). Counterknowledge: How We Surrendered to Conspiracy Theories, Quack Medicine, Bogus Science and Fake History. Atlantic Books. ISBN 1843546760
- "Patrick Holford Foreign Editions". Patrickholford.com. Retrieved 14 May 2013.
- Colquhoun, David (15 August 2007). "The age of endarkenment | Science | guardian.co.uk". London: Guardian. Retrieved 30 May 2009.
- Holford, Patrick. Patrick Holford: Profile howtoquit.co.uk. Accessed 29 May 2009.
- Doctored information on celebrity nutritionist, Ben Goldacre, The Guardian, 6 January 2007, retrieved 25 May 2010
- "Institute of Optimum Nutrition". Ion.ac.uk. Retrieved 14 May 2013.
- About Patrick Archived 25 November 2009 at the Wayback Machine.
- "IoP: Primary Care Mental Health". Iop.kcl.ac.uk. Retrieved 5 August 2009.
- STEEL, www.steel-london.co.uk. "Our mission". Food for the Brain. Retrieved 5 August 2009.
- "Brain Bio Centre". Foodforthebrain.org. Retrieved 14 May 2013.
- The British Association of Nutrition Therapy, "About BANT". Retrieved 7 January 2007.
- South African Association of Nutritional Therapy Archived 7 May 2010 at the Wayback Machine.
- "Irish Association of Nutritional Therapists". Iant.ie. 24 January 2012. Retrieved 14 May 2013.
- Damian Thompson (2008). "Counterknowledge". New York: Norton. OCLC 227016172
- Holford, Patrick. The New Optimum Nutrition Bible, Chapter 24. Retrieved 19 March 2007.
- Goldacre, Ben. "Vitamin deficiency". The Guardian, 6 January 2005. Retrieved 6 January 2007.
- Goldacre, Ben. "Working papers". The Guardian, 20 January 2005. Retrieved 6 January 2007.
- Holford, Patrick. Letter to The Guardian, 16 February 2007. Retrieved 19 March 2007.
- Jariwalla, Raxit. Letter to The Guardian, 20 January 2005. Retrieved 19 March 2007.
- How money is not the only barrier to Aids patients getting hold of drugs, Ben Goldacre, The Guardian, 17 February 2007, retrieved 25 May 2010
- | title=Autism |publisher=Foodforthebrain.org |date= |accessdate=3 February 2014
- Infectious Diseases and Immunization Committee, Canadian Paediatric Society (2007). "Autistic spectrum disorder: No causal relationship with vaccines". Paediatr Child Health 12 (5): 393–5. Retrieved 2008-10-17. Also published (2007) in Can J Infect Dis Med Microbiol 18 (3): 177–9. PMID 18923720.
- "Measles, mumps, and rubella (MMR) vaccine". Centers for Disease Control and Prevention. 22 August 2008. Archived from the original on 7 April 2008. Retrieved 2008-12-21.
- Institute of Medicine (US) Immunization Safety Review Committee (17 May 2004). "Immunization Safety Review: Vaccines and Autism". Institute of Medicine of the National Academy of Sciences. PMID 20669467. Retrieved 13 June 2007.
- "MMR The facts". NHS Immunisation Information. 2004. Archived from the original on 10 June 2012. Retrieved 2007-09-19.
- Demicheli V, Rivetti A, Debalini MG, Di Pietrantonj C (2012). "Vaccines for measles, mumps and rubella in children". Cochrane Database Syst Rev 2: CD004407. doi:10.1002/14651858.CD004407.pub3. PMID 22336803.
- Goodchild, Sophie and Owen, Jonathan. "Doctors warn against food fad dangers". The Independent on Sunday, 7 January 2007. Retrieved 18 January 2007.
- Patrick Holford (18 March 2007). "Doctors warn against food fad dangers – a clarification". London: News.independent.co.uk. Retrieved 30 May 2009.
- "ASA 2007 Judgement". Asa.org.uk. 19 September 2007. Retrieved 30 May 2009.
- "ASA 2003 Judgement". Cap.org.uk. 26 March 2003. Retrieved 30 May 2009.
- Patrick Holford's Website
- Food for the Brain
- The Brain Bio Centre
- Ben Goldacre's blog posts on Patrick Holford
- HolfordWatch, a critical blog
- HolfordMyths, an offshoot of Holford's main site providing answers to some of his criticisms
- Martin Walker's book on Patrick Holford and Ben Goldacre
- British Association of Nutritional Therapists
- Institute for Optimum Nutrition
- Nutritional Therapy Council