In 1994, Lussier was nominated at the Annual Gemini Awards for Best Picture Editing in a Dramatic Program or Series for Adrift and in 1995 he was nominated for Best Picture Editing in a Dramatic Program or Series for Heads.
In 1996, he edited the Doctor Who TV film and was praised by that film's producer for the extreme speed at which he was able to edit.
Lussier has been announced as director of the film Condition Dead and the adaptation of Michael Slade's Headhunter, produced by Brightlight Pictures and adapted by Wil Zmak. He directed the 2009 3D remake of My Bloody Valentine for Lionsgate Films, written by Zane Smith and Todd Farmer. On September 19, 2009, Lussier signed on to write and direct Halloween III, the third reboot of the Halloween franchise, originally scheduled for 2011 but later delayed. In 2010, Lussier directed Drive Angry, released on February 25, 2011. He co-wrote the screenplay with his previous collaborator Todd Farmer, of My Bloody Valentine 3D and the film starred Nicolas Cage, Amber Heard, William Fichtner, Billy Burke, and David Morse.Halloween 3-D was stopped and Lussier focused on Drive Angry. Lussier is in talks to direct the vampire thriller In Darkness. Lussier and his writing partner, Laeta Kalogridis, wrote the fifth film in the Terminator series, Terminator Genisys, for Paramount Pictures and Skydance Productions.