Patrick O. Brown

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For other people with the same name, see Patrick Brown (disambiguation).
Patrick O. Brown
Patrick O Brown.jpg
Pat Brown (Photo: Jane Gitschier)
Born Patrick O'Reilly Brown
1954 (age 61–62)[citation needed]
Washington, DC
Other names Pat
Nationality American
Fields Biochemistry
Institutions Stanford University
Alma mater University of Chicago
Thesis Studies on DNA Topoisomerases (1980)
Doctoral advisor Nicholas Cozzarelli
Known for DNA microarrays[1][2]
Public Library of Science
Notable awards NAS Award in Molecular Biology (2000)
Takeda award (2002)
Curt Stern Award (2005)

Patrick "Pat" O'Reilly Brown, M.D., Ph.D., (born 1954 in Washington, DC) is a Professor in the Department of Biochemistry at Stanford University.


Brown received each of his degrees from the University of Chicago, including his B.S. and M.D. His Ph.D., granted in 1980 while under the guidance of Nicholas R. Cozzarelli, involved the study of DNA topoisomerases.[3]


Following his PhD, Brown did his postdoctoral research with J. Michael Bishop and Harold Varmus at University of California, San Francisco.[3] His research uses DNA microarrays to study the gene expression patterns associated with especially cancer. He became an investigator of the Howard Hughes Medical Institute in 1988. He was elected to the United States National Academy of Sciences in 2002, identifying him as one of the top 2000 scientists in the nation. He is also a member of the Institute of Medicine and a Fellow of the American Association for the Advancement of Science.[4]

He is founder of Impossible Foods, a VC-funded stealth-mode startup using genetic engineering approaches to create plant-based "meat" and "cheese".[5]


In 2002 he received a Takeda award, recognizing his work in "the development of DNA microarrays with pre-synthesized DNA probes and the promotion of the technology by releasing the production methods on the Internet."[6]

In 2005 he received the Curt Stern Award for his contributions to the development and application of gene-based expression microarrays.[7]

In recognition of Brown's pioneering work in the development of microarrays and the diverse applications of this technology in genetic research, the Association of Biomolecular Resource Facilities (ABRF) selected him for the ABRF 2010 Award.

He is a co-founder of the Public Library of Science, an advocate of Open access publishing,[8] and a member of the Canary Foundation Science Team.


  1. ^ Schena, M.; Shalon, D.; Davis, R. W.; Brown, P. O. (1995). "Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray". Science 270 (5235): 467–470. doi:10.1126/science.270.5235.467. PMID 7569999. 
  2. ^ Eisen, M.; Spellman, P.; Brown, P.; Botstein, D. (1998). "Cluster analysis and display of genome-wide expression patterns". Proceedings of the National Academy of Sciences of the United States of America 95 (25): 14863–14868. doi:10.1073/pnas.95.25.14863. PMC 24541. PMID 9843981. 
  3. ^ a b Brown, P. O. (2013). "An interview with Patrick O Brown on the origins and future of open access". BMC Biology 11: 33–110. doi:10.1186/1741-7007-11-33. PMC 3626920. PMID 23587113. 
  4. ^ "HHMI Bio". HHMI. Retrieved 7 January 2013. 
  5. ^ "The Secret of These New Veggie Burgers: Plant Blood". WSJ. Retrieved 21 Apr 2015. 
  6. ^ "Takeda Award 2002 Achievements Fact Sheet" (PDF) (Press release). Takeda Foundation. Retrieved 2007-10-17. 
  7. ^ Eichler, Evan (2006). "Introductory Speech for Patrick O. Brown* * Previously presented at the annual meeting of the American Society of Human Genetics, in Salt Lake City, on October 29, 2005". The American Journal of Human Genetics 79 (3): 427–428. doi:10.1086/500330. PMC 1559547. PMID 16909379. 
  8. ^ Roberts, R. J.; Varmus, H. E.; Ashburner, M.; Brown, P. O.; Eisen, M. B.; Khosla, C.; Kirschner, M.; Nusse, R.; Scott, M. (2001). "Information Access: Building A GenBank of the Published Literature". Science 291 (5512): 2318a. doi:10.1126/science.1060273.