Paul L. Modrich
| Paul L. Modrich | |
|---|---|
| Born | Paul Lawrence Modrich June 13, 1946 Raton, New Mexico, USA |
| Nationality | United States |
| Fields | DNA mismatch repair |
| Institutions | |
| Alma mater | MIT, Stanford University (PhD) |
| Known for | Clarification of cellular resistance to carcinogens |
| Notable awards |
Nobel Prize in Chemistry (2015)
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| Website Paul L. Modrich |
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Paul Lawrence Modrich (born June 13, 1946) is the James B. Duke Professor of Biochemistry at Duke University and Investigator at the Howard Hughes Medical Institute. He received a Ph.D. degree in 1973 from Stanford University and an B.S. degree in 1968 from MIT. He is known for his research on DNA mismatch repair.[1]
Research[edit]
Modrich joined Duke University's faculty in 1976 and has been a Howard Hughes Investigator since 1994. He works primarily on strand-directed mismatch repair. His lab demonstrated how DNA mismatch repair serves as a copyeditor to prevent errors from DNA polymerase. Matthew Meselson previously proposed the existence of recognition of mismatches. Modrich performed biochemical experiments to study mismatch repair in E. coli.[2] They later searched for proteins associated with mismatch repair in humans.[1]
Awards[edit]
He has been awarded the Nobel Prize in Chemistry 2015 jointly with Aziz Sancar and Tomas Lindahl.[3][4]
Dr. Modrich is also a fellow of the American Academy of Arts and Sciences, and a member of the Institute of Medicine and the National Academy of Sciences.
References[edit]
- ^ a b "Paul Modrich Awarded 2015 Nobel Prize in Chemistry". HHMI. HHMI. October 7, 2015. Retrieved October 7, 2015.
- ^ Su, SS; Modrich, P (July 1986). "Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs.". Proceedings of the National Academy of Sciences of the United States of America 83 (14): 5057–61. PMID 3014530.
- ^ Broad, William J. (October 7, 2015). "Nobel Prize in Chemistry Awarded to Tomas Lindahl, Paul Modrich and Aziz Sancar for DNA Studies". The New York Times. ISSN 0362-4331. Retrieved October 7, 2015.
- ^ Staff (7 October 2015). "THE NOBEL PRIZE IN CHEMISTRY 2015 - DNA repair – providing chemical stability for life" (PDF). Nobel Prize. Retrieved 7 October 2015.
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- 1946 births
- Nobel laureates in Chemistry
- Duke University faculty
- Stanford University alumni
- American Nobel laureates
- American biochemists
- Howard Hughes Medical Investigators
- Living people
- Members of the United States National Academy of Sciences
- Fellows of the American Academy of Arts and Sciences
- People from Colfax County, New Mexico