Paxilline

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Paxilline
Paxilline.png
Names
IUPAC name
(2R,​4bS,​6aS,​12bS,​12cR,​14aS)-​4b-​hydroxy-​2-​(1-​hydroxy-​1-​methylethyl)-​12b,​12c-​dimethyl-​5,​6,​6a,​7,​12,​12b,​12c,​13,​14,​14a-​decahydro-​2H-​chromeno​[5',6':​6,7]​indeno​[1,2-​b]​indol-​3(4bH)-​one
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.164.932
MeSH Paxilline
Properties
C27H33NO4
Molar mass 435.56 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Paxilline is a potassium channel blocker. Paxilline is a toxic, tremorgenic indole alkaloid produced by Penicillium paxilli .[1] Paxilline was found to significantly extend the lifespan healthspan and mobility of C. elegans aged worms, but had no such effect on young worms. [2]

Sources and references[edit]

  1. ^ Paxilline product page from Fermentek
  2. ^ Li, Guang; Gong, Jianke; Liu, Jie; Liu, Jinzhi; Li, Huahua; Hsu, Ao-Lin; Liu, Jianfeng; Xu, X.Z. Shawn (2019). "Genetic and pharmacological interventions in the aging motor nervous system slow motor aging and extend life span in C. Elegans". Science Advances. 5: eaau5041. doi:10.1126/sciadv.aau5041.