|Systematic (IUPAC) name|
|Molecular mass||478.928 g/mol|
|(what is this?)|
Pazinaclone has a very similar pharmacological profile to the benzodiazepine family of drugs including sedative and anxiolytic properties, but with less amnestic effects, and at low doses it is a relatively selective anxiolytic, with sedative effects only appearing at higher doses.
Reaction of 2-Amino-7-chloro-1,8-naphthyridine with phthalic anhydride leads to the corresponding phthalimide. Selective reduction of one of the imide carbonyl groups in essence converts that to an aldehyde. Condensation with tert-Butyl(triphenylphosphoranylidene)acetate gives the Wittig product.
The carboxylic acid is then treated with Diethyl cyanophosphonate to convert that to an activated acid cyanide; reaction with 1,4-Dioxa-8-azaspiro(4.5)decane results in formation of the corresponding amide, pazinaclone.
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