She was the vocalist of mid-1990s indie bands Powder and Lodger, which she fronted after a brief period at LAMDA, and as a solo-artist under the name Pearl.
In 2001 she launched 'Pearl Lowe', her signature range of lacecurtains and cushions. In 2006 she began designing her own bespoke handmade dresses that were sold to Liberty and The Cross in London. She also designs capsule ranges for the budget chain Peacocks.
Lowe published her memoir All That Glitters in 2007, a sombre look at overcoming addiction.
Lowe's family was originally from Bethnal Green. Her mother, Leila, was an interior designer, and her father, Eddie, a bouncer. Since 1995, her partner has been Supergrass drummer Danny Goffey, with whom she has three children. Goffey and Lowe married on 4 December 2008 in Babington House, Somerset.