She was the vocalist of mid-1990s indie bands Powder and Lodger, which she fronted after a brief period at LAMDA, and as a solo-artist under the name Pearl.
In 2001 she launched 'Pearl Lowe', her signature range of lacecurtains and cushions. In 2006 she began designing her own bespoke handmade dresses that were sold to Liberty and The Cross in London. She also designs capsule ranges for the budget chain Peacocks.
Lowe published her memoir All That Glitters in 2007, a sombre look at overcoming addiction.