|Classification and external resources|
Pel-Ebstein fever, also known as Ebstein-Cardarelli fever, is a rarely seen condition noted in patients with Hodgkin's lymphoma in which the patient experiences fevers which cyclically increase then decrease over an average period of one or two weeks. A cyclic fever may also be associated with other conditions, but it is not called "Pel-Ebstein fever" unless the fever is associated with Hodgkin's.
The condition is named after Wilhelm Ebstein and P.K. Pel who both published papers in 1887 noting the phenomenon. Both doctors published in the same journal, though Pel published first by several months. A long-term dispute persisted between Pel and Ebstein on the etiology of the condition.
Researchers have speculated whether this condition truly exists, since some authorities anecdotally estimate only a 5-10% occurrence rate. In his Lettsomian Lecture Making Sense, delivered to the Medical Society of London in 1959, Richard Asher refers to Pel-Ebstein fever as an example of a condition that exists only because it has a name. "Every student and every doctor knows that cases of Hodgkin's disease may show a fever that is high for one week and low for the next week and so on. Does this phenomenon really exist at all?..." 
- G.Fradà- Semeiotica Medica nell' adulto e nell'anziano. Piccin p.48
- Mauch, Peter; James Armitage; Volker Diehl; Richard Hoppe; Laurence Weiss (1999). Hodgkin's Disease. Lippincott Williams & Wilkins. pp. 327–328. ISBN 0-7817-1502-4.
- "eMedicine - Pel-Ebstein Fever : Article by Ephraim P Hochberg, MD". Retrieved 2007-07-08.
- Ree, HJ (1987). "Stromal macrophage-histiocytes in Hodgkin's disease. Their relation to fever". Cancer. 60 (1479): 1479–84. doi:10.1002/1097-0142(19871001)60:7<1479::AID-CNCR2820600713>3.0.CO;2-G. PMID 3621125.
- Ebstein, Wilhelm (1887). "Das chronische Ruckfallsfieber, eine neue Infectionskrankheit". Berlin Klin Wochenschr. 24 (565).
- Pel, PK (1887). "Pseudoleukaemie oder chronisches Ruckfallsfieber?". Berlin Klin Wochenschr. 24 (565).
- synd/438 at Who Named It?
- Hilson, A.J.W.; DiNubile, M.J. (1995-07-06). "Correspondence". New England Journal of Medicine. 333 (1): 66–67. doi:10.1056/NEJM199507063330118. PMID 7777006. Retrieved 2008-03-18.. They cite Richard Asher's lecture Making Sense (Lancet, 1959, 2, 359)