The intro used the same beat as N.W.A's "efil4zaggin" album intro. Tim taunted "I stole your beat and made it better, to show the whole world that you ain't nothing but a bunch of pussies" before a number of disparaging answering machine messages supported Tim's position. Tim rapped: "Wearing all that black, driving them cars, but you still look wack!"
A skit called "DJ Quik Beat Down" was a forty-second audio snippet of Tim Dog physically assaulting DJ Quik.
The track "Step To Me" taunted Compton rappers and included the line "DJ Quik he can suck my dick".
"Michel'le Conversation" was a skit where a Michel'le soundalike called Tim Dog to complain about Tim's Compton diss, but then ended up admitting she was "tired of him (Dre) beating down on me" and for Tim to "Call me when you're in town".
The track "Goin Wild in the Penile" included an intro whereby Tim had recently been released from prison for shooting a "Compton kid".
AllMusic's Ron Wynn gave Penicillin on Wax an "Album Pick" tag, saying "Bronx rapper Tim Dog informed the world what he thought of West Coast types with the single "F--- Compton." It was the definitive composition on his debut album, setting the stage for a series of angry, often vicious and sneering taunts, challenges, boasts and putdowns."Entertainment Weekly writer James Bernard commended Tim's "deep and ominous" vocals for delivering "attention-grabbing moments" at times but felt the album gets weighted down with Tim's lyrical tirades against N.W.A over unspectacular beats, concluding that "Yes, "dissing" is a proud rap tradition, but such one-note obsession gets pretty boring. Move on, Tim Dog, move on."Robert Christgau cited "Fuck Compton" as a "choice cut", indicating a good song on "an album that isn't worth your time or money." In a retrospective review, DJ Fatboy of RapReviews praised the overall production throughout the album, Tim's "forceful" delivery of his absurd lyricism despite wishing he craft better lyrics and Kool Keith's guest contributions on "I Ain't Havin' It" and "Secret Fantasies", concluding that, "Great production values, utter craziness. Although it's debatable whether or not it was Tim's intent to be that fuckin out there, it's no question this was one of the most entertaining albums to come out of the early 90s, point blank."