Pentedrone

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Pentedrone
Pentedrone.svg
Systematic (IUPAC) name
(±)-1-phenyl-2-(methylamino)pentan-1-one
Legal status
Legal status
Identifiers
CAS Number 879722-57-3 N
ATC code none
PubChem CID 71750191
ChemSpider 26286729 YesY
UNII 2ELU1B757Q YesY
Chemical data
Formula C12H17NO
Molar mass 191.269 g/mol
 NYesY (what is this?)  (verify)

Pentedrone (also known as α-methylamino-valerophenone) is a stimulant of the cathinone class that has been sold as a designer drug and has been found since 2010 as an ingredient in a number of "bath salt" mixes sold as legal highs.[1][2][3][4][5][6][7]

Pharmacology[edit]

Pentedrone acts as a norepinephrine-dopamine reuptake inhibitor without causing their release, the same mechanism of action as methylphenidate.[8][9]

Side effects[edit]

Pentedrone has been linked to at least one death where it was combined with α-PVP and caused heart failure.[10]

Detection[edit]

A forensic standard of Pentedrone is available, and the compound has been posted on the Forendex website of potential drugs of abuse.[11]

Legal status[edit]

On January 28, 2014, the DEA listed it, along with 9 other synthetic cathinones, on the Schedule 1 with a temporary ban, effective February 27, 2014.[12]

Pentedrone is a Anlage II controlled drug in Germany.

As of October 2015 Pentedrone is a controlled substance in China.[13]

Pentedrone is banned in the Czech Republic.[14]

See also[edit]

References[edit]

  1. ^ EMCDDA Annual Report 2010
  2. ^ Research on Head Shop drugs in Dublin: Part 2
  3. ^ An overview of new psychoactive substances and the outlets supplying them
  4. ^ Folker Westphall; Thomas Junge; Ulrich Girreser; Wolfgang Greibl; Carmen Doering (April 2012). "Mass, NMR and IR spectroscopic characterization of pentedrone and pentylone and identification of their isocathinone by-products". Forensic Science International. 217 (1-3): 157–167. doi:10.1016/j.forsciint.2011.10.045. PMID 22115724. 
  5. ^ Chad R. Maheux; Catherine R. Copeland (January 2012). "Chemical analysis of two new designer drugs: buphedrone and pentedrone". Drug Testing and Analysis. 4 (1): 17–23. doi:10.1002/dta.385. PMID 22113925. 
  6. ^ Justin L. Poklis; Carl E. Wolf; Omar I. ElJordi; Kai Liu; Shijun Zhang; Alphonse Poklis (January 2015). "Analysis of the First- and Second-Generation Raving Dragon Novelty Bath Salts Containing Methylone and Pentedrone". Journal of Forensic Sciences. 60 (11): 234–240. doi:10.1111/1556-4029.12629. PMID 25470207. 
  7. ^ Victor M.R. Zancajo; J. Brito; Marta P. Carrasco; M.R. Bronze; Rui Moreira; Alvaro Lopes (November 2014). "Analytical profiles of "legal highs" containing cathinones available in the area of Lisbon, Portugal". Forensic Science International. 244: 102–110. doi:10.1016/j.forsciint.2014.08.010. PMID 25240621. 
  8. ^ Simmler, L. D.; Rickli, A.; Hoener, M. C.; Liechti, M. E. (2014). "Monoamine transporter and receptor interaction profiles of a new series of designer cathinones". Neuropharmacology. 79: 152–60. doi:10.1016/j.neuropharm.2013.11.008. PMID 24275046. 
  9. ^ Ji-Young Hwang; Jun-Sub Kim; Ji-Hwan Oh; Sa-Ik Hong; Shi-Xun Ma; Yang-Hee Jung; Yong-Hyun Ko; Seok-Yong Lee; Hyoung-Chun Kim; Choon-Gon Jang (August 2015). "The new stimulant designer compound pentedrone exhibits rewarding properties and affects dopaminergic activity". Addiction Biology. doi:10.1111/adb.12299. PMID 26290055. 
  10. ^ Sykutera, M.; Cychowska, M.; Bloch-Boguslawska, E. (March 2015). "A Fatal Case of Pentedrone and -Pyrrolidinovalerophenone Poisoning". Journal of Analytical Toxicology. 39 (4): 324–329. doi:10.1093/jat/bkv011. PMID 25737339. 
  11. ^ "Pentedrone". Southern Association of Forensic Scientists. Retrieved 8 September 2015. 
  12. ^ "Temporary Placement of 10 Synthetic Cathinones into Schedule I". 28 January 2014. 
  13. ^ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Retrieved 1 October 2015. 
  14. ^ "Látky, o které byl doplněn seznam č. 4 psychotropních látek (příloha č. 4 k nařízení vlády č. 463/2013 Sb.)" (PDF) (in Czech). Ministerstvo zdravotnictví.