The son of flamenco guitarist Antonio Sánchez Pecino, and the brother of flamenco guitarists Paco de Lucía and Ramón de Algeciras, he adopted the stage name Pepe de Lucía in honor of his Portuguese mother, Lúcia Gomes. He is the father of Spanish pop singer Malú. He released his debut recording, Los Chiquitos de Algeciras, with his brother Paco de Lucía in 1961. He continued to sing on his brother's albums until 1988, when he was replaced by Duquende. His son, José de Lucía is also a flamenco musician, like his uncle, father and grandfather.