|Headquarters||Two Logan Square
|No. of offices||13 offices|
|No. of attorneys||approximately 500|
|No. of employees||approximately 1,200 total|
|Major practice areas||General practice|
|Revenue||$324.6 million (2011)|
|Founder||George Wharton Pepper|
|Company type||Limited liability partnership|
|Slogan||We counsel each client as if it were our only client.|
Pepper Hamilton LLP is a U.S. based law firm with 13 offices and around 500 attorneys. The firm is ranked among the 100 largest firms by revenue in the United States. The firm’s largest practices include defense of pharmaceutical and medical device manufacturers in product liability litigation and related matters, corporate transactions and commercial litigation.
The firm was founded in 1890 in Philadelphia by George Wharton Pepper, who joined the practice of Bayard Henry. Pepper emerged as a leading lawyer in Philadelphia and the nation, and was prominent in Republican politics. In 1954, the Pepper firm and another Philadelphia law firm — Evans, Bayard & Frick — merged as Pepper, Bodine, Frick, Scheetz & Hamilton creating a 35-lawyer entity. Shortly after the merger of the Pepper and Evans firms, George Wharton Pepper retired from practice because of failing health. In 1955, he was succeeded as chairman of the firm by John D.M. Hamilton, who was chairman of the Republican National Committee in 1940. In 1960, another merger brought in the firm of Moffett, Frye & Leopold. The firm grew significantly in the 1980s, 1990s and in recent years. In 2007, the partnership elected Nina M. Gussack as chairwoman of Pepper’s Executive Committee, the first woman to be elected to that position. Pepper partner A. Michael Pratt became the Philadelphia Bar Association’s 81st Chancellor in 2008. He is the third African-American to serve in that office since the Association’s founding in 1802.
In 2004–2005, Pepper was hit with lawsuits first in the U.S. Bankruptcy Court and then the District Court in Delaware. The first lawsuit alleged that "Pepper Hamilton's simultaneous representation of SFC and its affiliates, as well as its insurer, Royal Indemnity, and the Gagne family members as investors, created a situation in which the law firm had 'unavoidable and inevitable divided loyalties.'" Thus the complaint alleged that Pepper "foreseeably contributed to the financial demise of SFC" and caused "hundreds of millions of dollars of harm."
In the second lawsuit, Royal Indemnity made malpractice claims against Pepper Hamilton and Gagne, as well as two accounting firms, Freed Maxick & Battaglia and McGladrey & Pullen, alleging that the lawyers and accountants garnered millions in fees from SFC and were effective "SFC insiders" who "had every incentive to ensure the success of SFC's fraud."
Pepper settled the lawsuits in late 2007.
- Federal Baseball Club v. National League
- Myers v. United States
- United States v. Smith, 286 U.S. 6 (1932)
- Sugar Monopoly Case
- Northern Securities Case
- Standard Oil Company and United States Steel anti-monopoly defenses
- Kitzmiller v. Dover Area School District (plaintiff's rep)
- Representation of Guantanamo Bay Detainees 
- Eli Lilly and Company and State of Alaska Settle Zyprexa Lawsuit Eli Lilly
The firm's chairman is Thomas M. Gallagher, who succeeds Louis Freeh (Feb 2013—Oct 2014). Prior to Freeh, Nina Gussak held this role.
- 1890 – Philadelphia, PA
- 1969 – Harrisburg, PA
- 1969 – Washington, D.C.
- 1979 – Detroit, MI
- 1983 – Wilmington, DE
- 1984 – Berwyn, PA
- 1990 – New York, NY
- 1995 – Pittsburgh, PA
- 2001 – Princeton, NJ
- 2004 – Orange County, CA
- 6 lawyers as of July 2013
- 2006 – Boston, MA
- 2012 – Los Angeles
- 12 lawyers as of July 2013
- 2013 – Silicon Valley, CA 
- "Organizational profile of Pepper Hamilton LLP". The National Law Review.
- Mondics,Chris. Female law-firm head: 'Not a big deal', The Philadelphia Inquirer, November 26, 2007. Accessed December 22, 2014.
- Mondics,Chris. Bar's new chancellor aims at tax, diversity, The Philadelphia Inquirer, December 04, 2007. Accessed December 22, 2014.
- "Pepper Hamilton Opens Silicon Valley Office - New Office Marks Third Pepper Office in California". 12 November 2013. Retrieved 28 January 2014.