Pepscan is a procedure for mapping and characterizing epitopes involving the synthesis of overlapping peptides and analysis of the peptides in enzyme-linked immunosorbent assays (ELISAs). The method is based on combinatorial chemistry and was pioneered by Mario Geysen and coworkers.
- Geysen M, et al (1984). Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid. PNAS, July 1, 1984 vol. 81 no. 13 3998-4002