Peptide transporter 1

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SLC15A1
Identifiers
AliasesSLC15A1, HPECT1, HPEPT1, PEPT1, Peptide transporter 1, solute carrier family 15 member 1
External IDsMGI: 1861376 HomoloGene: 38006 GeneCards: SLC15A1
Gene location (Human)
Chromosome 13 (human)
Chr.Chromosome 13 (human)[1]
Chromosome 13 (human)
Genomic location for SLC15A1
Genomic location for SLC15A1
Band13q32.2-q32.3Start98,683,801 bp[1]
End98,752,654 bp[1]
RNA expression pattern
PBB GE SLC15A1 211349 at fs.png

PBB GE SLC15A1 207254 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005073

NM_053079

RefSeq (protein)

NP_005064

NP_444309

Location (UCSC)Chr 13: 98.68 – 98.75 MbChr 14: 121.46 – 121.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Peptide transporter 1 (PepT 1) also known as solute carrier family 15 member 1 (SLC15A1) is a protein that in humans is encoded by SLC15A1 gene.[5][6] PepT 1 is a solute carrier for oligopeptides. It functions in renal oligopeptide reabsorption and in the intestines in a proton dependent way, hence acting like a cotransporter.[7]

Function[edit]

SLC15A1is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs.[5][7]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000088386 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025557 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: SLC15A1 Solute carrier family 15 (oligopeptide transporter), member 1". 
  6. ^ Liang R, Fei YJ, Prasad PD, Ramamoorthy S, Han H, Yang-Feng TL, Hediger MA, Ganapathy V, Leibach FH (March 1995). "Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization". J. Biol. Chem. 270 (12): 6456–63. doi:10.1074/jbc.270.12.6456. PMID 7896779. 
  7. ^ a b Adibi SA (July 1997). "The oligopeptide transporter (Pept-1) in human intestine: biology and function". Gastroenterology. 113 (1): 332–40. doi:10.1016/S0016-5085(97)70112-4. PMID 9207295. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.