Peptidylamidoglycolate lyase

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peptidylamidoglycolate lyase
Identifiers
EC number 4.3.2.5
CAS number 131689-50-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a peptidylamidoglycolate lyase (EC 4.3.2.5) is an enzyme that catalyzes the chemical reaction

peptidylamidoglycolate peptidyl amide + glyoxylate

Hence, this enzyme has one substrate, peptidylamidoglycolate, and two products, peptidyl amide and glyoxylate.

This enzyme belongs to the family of lyases, specifically amidine lyases. The systematic name of this enzyme class is peptidylamidoglycolate peptidyl-amide-lyase (glyoxylate-forming). Other names in common use include alpha-hydroxyglycine amidating dealkylase, peptidyl-alpha-hydroxyglycine alpha-amidating lyase, HGAD, PGL, PAL, and peptidylamidoglycolate peptidylamide-lyase.

References[edit]

  • Katopodis AG, Ping D, May SW (1990). "A novel enzyme from bovine neurointermediate pituitary catalyzes dealkylation of alpha-hydroxyglycine derivatives, thereby functioning sequentially with peptidylglycine alpha-amidating monooxygenase in peptide amidation". Biochemistry. 29 (26): 6115–20. doi:10.1021/bi00478a001. PMID 2207061.