In 1901, he moved up to the Football League when he joined Notts County where he spent six seasons, making 202 appearances in total, scoring 73 goals. During these six seasons, County consistently finished in the lower half of the First Division table.
Humphreys swapped places with Woodward moving across London to join Tottenham Hotspur. Humphreys only made 45 league appearances for Spurs, scoring 24 goals, none of which were as vital as the one that he scored against Chelsea in the final match of the 1909–10 season which ensured that Chelsea were relegated instead of Spurs. In the following season he was unable to hold down a regular place in the Spurs side, with Billy Minter being preferred at inside-right.
In October 1911, he was transferred back to Leicester Fosse where he spent the rest of the season, before dropping out of the league to join Hartlepools United.