Sir Percy Scott Worthington (31 January 1864 – 15 July 1939) was an English architect.
He was born in Crumpsall, Manchester, the eldest son of the architect Thomas Worthington. He was educated at Clifton College, Bristol and Corpus Christi College, Oxford, where he graduated in 1887, and he qualified as an architect in 1890. He became a partner in his father's firm the following year. He subsequently worked as assistant to John Macvicar Anderson in London, attending the Royal Academy Schools and University College London, before returning to his father's office where he was made a partner in 1891. He continued the business after his father's death along with his much younger brother Hubert Worthington, who became a partner in 1913. Percy's son Thomas Scott Worthington later joined the partnership.
In his early years he was interested in the Arts and Crafts movement and this was reflected in the Unitarian Chapel, Liverpool, which he designed with his father. From 1904 he became more involved in the revival of classicism. He was awarded the gold medal of the Royal Institute of British Architects in 1930 and was knighted in 1935. He died at his home in Mobberley, Cheshire, in 1939.
In a professional life of almost fifty years Worthington was responsible for more than a hundred projects—domestic, educational, ecclesiastical, and medical—and won many of his major commissions in competition. His work on hospitals was described by his obituarist and confrère W. G. Newton as pioneering.
- War Memorial Cottage Hospital, Northwich Road, Knutsford
- Kerfield House, Chelford Road, Knutsford 
- Radbroke Hall, Peover Superior 
- Woodgarth, Legh Road Knutsford
- Convalescent Home, Great Warford
- War Memorial, Mobberley, Cheshire 
- Manchester Grammar School
- Archer, John H. G. (2007) , "Worthington family (per. 1849–1963)", Oxford Dictionary of National Biography, Oxford University Press, retrieved 11 September 2013 ((subscription or UK public library membership required))
- John H. G. Archer, ‘Worthington family (per. 1849–1963)’, Oxford Dictionary of National Biography, Oxford University Press, 2004; online edn, Oct 2007 accessed 26 April 2016
- Hartwell, C et al (2011) The Buildings of England: Cheshire. London: Yale University Press. pg 422
- Cheshire East Council (2010) Local List of Historic Buildings.
- d De Figueiredo, Peter; Treuherz, Julian (1988), Cheshire Country Houses, Chichester: Phillimore, pp. 150–153, ISBN 0-85033-655-4
- Hartwell, C et al (2011) The Buildings of England: Cheshire. London: Yale University Press. pg 428
- Hartwell, C et al (2011) The Buildings of England: Cheshire. London: Yale University Press. pg 382
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