Perflubron

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Perflubron
Perflubron structure.svg
Systematic (IUPAC) name
1-Bromo-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane
Identifiers
CAS Number 423-55-2
ATC code V08CX01 (WHO)
PubChem CID 9873
ChemSpider 9489
UNII Q1D0Q7R4D9 YesY
ChEMBL CHEMBL1200866
Chemical data
Formula C8BrF17
Molar mass 498.96 g/mol
Physical data
Density 1.93 g/cm3
Melting point 6 °C (43 °F)
Boiling point 142 °C (288 °F)

Perflubron (INN/USAN, or perfluorooctyl bromide; brand name Imagent) is a contrast medium for magnetic resonance imaging, computer tomography and sonography.[1] It was approved for this use in the United States by the Food and Drug Administration in 1993.[2]

Experimental research[edit]

For more information on this potential application, see Liquid breathing § Medical treatment.

Perflubron has also been tested experimentally for use in liquid breathing in premature infants with respiratory distress.[3][4]

This molecular model of Perflubron is color-coded by electron density to illustrate the positive polarisation of the large bromine atom by the inductively electron-withdrawing perfluorooctyl chain.

References[edit]

  1. ^ Mattrey, R. F. (1989). "Perfluorooctylbromide: A new contrast agent for CT, sonography, and MR imaging". AJR. American journal of roentgenology 152 (2): 247–252. doi:10.2214/ajr.152.2.247. PMID 2643258. 
  2. ^ FDA Approved Drug Products
  3. ^ Wolfson, M. R.; Kechner, N. E.; Roache, R. F.; Dechadarevian, J. P.; Friss, H. E.; Rubenstein, S. D.; Shaffer, T. H. (1998). "Perfluorochemical rescue after surfactant treatment: Effect of perflubron dose and ventilatory frequency". Journal of applied physiology (Bethesda, Md. : 1985) 84 (2): 624–640. PMID 9475875. 
  4. ^ Leach, C. L.; Greenspan, J. S.; Rubenstein, S. D.; Shaffer, T. H.; Wolfson, M. R.; Jackson, J. C.; Delemos, R.; Fuhrman, B. P. (1996). "Partial Liquid Ventilation with Perflubron in Premature Infants with Severe Respiratory Distress Syndrome". New England Journal of Medicine 335 (11): 761–767. doi:10.1056/NEJM199609123351101. PMID 8778584.