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Systematic (IUPAC) name
Clinical data
Legal status
  • Legal
Routes of
CAS Number 84638-28-8 YesY
ATC code None
PubChem CID 6440735
ChemSpider 4944986
Chemical data
Formula C19H22N2
Molar mass 278.391 g/mol

Pericine is one of a number of indole alkaloids found in the tree Picralima nitida, commonly known as Akuamma. The dried seeds from this plant are used in traditional medicine throughout West Africa, particularly in Ghana as well as in the Ivory Coast and Nigeria. As with some other alkaloids from this plant such as akuammine, pericine has been shown to bind to mu opioid receptors, and has an IC50 of 0.6 μmol, around 6x more potent than codeine when tested in the same assay.[1] However it may also have convulsant effects.[2]

See also[edit]


  1. ^ Arens, H.; Borbe, H. O.; Ulbrich, B.; Stöckigt, J. (Dec 1982). "Detection of Pericine, a New CNS-active Indole Alkaloid from Picralima nitida Cell Suspension Culture by Opiate Receptor Binding Studies". Planta Medica 46 (12): 210–214. doi:10.1055/s-2007-971216. PMID 6298847. 
  2. ^ Roberts, M. F.; Wink, M. Alkaloids: Biochemistry, Ecology, and Medicinal Applications. pp. 68–69. ISBN 978-0-306-45465-3.