Peripherally selective drug

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Peripherally selective drugs have their primary mechanism of action outside of the central nervous system (CNS), usually because they are excluded from the CNS by the blood-brain barrier. By being excluded from the CNS, drugs may act on the rest of the body without producing side-effects related to their effects on the brain or spinal cord. For example, most opiates cause sedation when given at a sufficiently high dose, but peripherally selective opiates can act on the rest of the body without entering the brain and are less likely to cause sedation.[1]



  1. ^ Stein, C; Zöllner, C (2009). "Opioids and sensory nerves". Handbook of experimental pharmacology (194): 495–518. doi:10.1007/978-3-540-79090-7_14. PMID 19655116.

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