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Available structures
PDB Ortholog search: PDBe RCSB
Aliases PPL, periplakin
External IDs MGI: 1194898 HomoloGene: 2026 GeneCards: PPL
RNA expression pattern
PBB GE PPL 203407 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 16: 4.88 – 4.96 Mb Chr 16: 5.09 – 5.13 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Periplakin is a protein that in humans is encoded by the PPL gene.[3][4][5]

The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.[5]


PPL (gene) has been shown to interact with Keratin 8[6] and Envoplakin.[7][8]

See also[edit]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Ruhrberg C, Williamson JA, Maatta A, Watt FM (Jun 1998). "The periplakin gene maps to 16p13.3 in human and 16A-B1 in mouse". Genomics. 49 (1): 157–9. PMID 9570964. doi:10.1006/geno.1997.5206. 
  4. ^ Aho S, McLean WH, Li K, Uitto J (Jun 1998). "cDNA cloning, mRNA expression, and chromosomal mapping of human and mouse periplakin genes". Genomics. 48 (2): 242–7. PMID 9521878. doi:10.1006/geno.1997.5188. 
  5. ^ a b "Entrez Gene: PPL periplakin". 
  6. ^ Kazerounian, Shideh; Uitto Jouni; Aho Sirpa (Oct 2002). "Unique role for the periplakin tail in intermediate filament association: specific binding to keratin 8 and vimentin". Exp. Dermatol. Denmark. 11 (5): 428–38. ISSN 0906-6705. PMID 12366696. doi:10.1034/j.1600-0625.2002.110506.x. 
  7. ^ Karashima, Tadashi; Watt Fiona M (Dec 2002). "Interaction of periplakin and envoplakin with intermediate filaments". J. Cell. Sci. England. 115 (Pt 24): 5027–37. ISSN 0021-9533. PMID 12432088. doi:10.1242/jcs.00191. 
  8. ^ Ruhrberg, C; Hajibagheri M A; Parry D A; Watt F M (Dec 1997). "Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin". J. Cell Biol. UNITED STATES. 139 (7): 1835–49. ISSN 0021-9525. PMC 2132639Freely accessible. PMID 9412476. doi:10.1083/jcb.139.7.1835. 

Further reading[edit]