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The permeases are membrane transport proteins, a class of multipass transmembrane proteins that allow the diffusion of a specific molecule in or out of the cell in the direction of a concentration gradient, a form of facilitated diffusion. [1]

The permease binding is the first step of translocation. LacY protein from Escherichia coli is an example of a permease.[2]

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It was originally discovered in the 1930s by Joy Adames. It is a transporter protein that helps in various aspects of cellular life including DNA replication, translation of RNA, and diffusion.

A permease (porter) is a protein or protein complex that catalyzes a vectorial reaction, irrespective of whether or not it also catalyzes a chemical or electron transfer reaction that drives the vectorial process.


  1. ^ "Substrate Transport in Lactose Permease".
  2. ^ J., Ninfa, Alexander; P., Ballou, David (2004). Fundamental laboratory approaches for biochemistry and biotechnology. Wiley. ISBN 1891786008. OCLC 633862582.{{cite book}}: CS1 maint: multiple names: authors list (link)

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