Peroxiredoxin 2

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PRDX2
Protein PRDX2 PDB 1qmv.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PRDX2, HEL-S-2a, NKEF-B, NKEFB, PRP, PRX2, PRXII, PTX1, TDPX1, TPX1, TSA, Peroxiredoxin 2
External IDs MGI: 109486 HomoloGene: 21182 GeneCards: PRDX2
Gene location (Human)
Chromosome 19 (human)
Chr. Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for PRDX2
Genomic location for PRDX2
Band No data available Start 12,796,820 bp[1]
End 12,801,859 bp[1]
RNA expression pattern
PBB GE PRDX2 39729 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_181738
NM_005809
NM_181737

NM_011563
NM_001317385

RefSeq (protein)

NP_005800

NP_001304314
NP_035693

Location (UCSC) Chr 19: 12.8 – 12.8 Mb Chr 19: 84.97 – 84.97 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Peroxiredoxin-2 is a protein that in humans is encoded by the PRDX2 gene.[5][6]

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. The crystal structure of this protein has been resolved to 0.27 nm (= 2.7 angstroms). Transcript variants encoding distinct isoforms have been identified for this gene.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167815 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000005161 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Pahl P, Berger R, Hart I, Chae HZ, Rhee SG, Patterson D (Aug 1995). "Localization of TDPX1, a human homologue of the yeast thioredoxin-dependent peroxide reductase gene (TPX), to chromosome 13q12". Genomics. 26 (3): 602–6. PMID 7607688. doi:10.1016/0888-7543(95)80183-M. 
  6. ^ a b "Entrez Gene: PRDX2 peroxiredoxin 2". 

Further reading[edit]