A post office was established as Persia in 1868, and remained in operation until it was discontinued in 1967. Persia was a station on the East Tennessee, Virginia and Georgia Railway, which was founded in 1869.
Persia once had a post office; the closest post office now is in Rogersville. Persia shares Rogersville's ZIP code, 37857.
Cherokee High School is located in Persia.
- U.S. Geological Survey Geographic Names Information System: Persia, Tennessee
- "Hawkins County". Jim Forte Postal History. Retrieved 6 December 2014.
- Tennessee State Gazetteer and Business Directory. R.L. Polk & Company. 1876. p. 335.