Persistent aura without infarction

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Persistent migraine aura without infarction (PAWOI) is a little-known condition, first described under the designation prolonged migraine aura status,[1] that is not yet fully understood. PAWOI is said to be a possible cause of a variety of neurological symptoms, including visual snow, loss of vision, increased afterimages, tinnitus, and others.[2] However, the pathogenesis of PAWOI is unknown; in other words, it is not known exactly what causes these symptoms. Furthermore, it is not clear which medical examinations are useful in diagnosing PAWOI. At present, PAWOI is usually diagnosed solely based on the patient's present and past symptoms. It may be possible that an overactive brain or a chemical imbalance is partly to blame for the disorder. Different medication has been tried as treatment, notably acetazolamide,[3] valproate,[4] lamotrigine,[5] topiramate, and furosemide.[6]


  1. ^ Haas DC. Prolonged migraine aura status. Ann Neurol 1982; 11: 197-199
  2. ^ Migraine Aura Foundation
  3. ^ Haan J, Sluis P, Sluis LH, Ferrari MD. Acetazolamide treatment for migraine aura status. Neurology 2000; 55: 1588-1589.
  4. ^ Rothrock JF. Successful treatment of persistent migraine aura with divalproex sodium. Neurology 1997; 48: 261-262.
  5. ^ Chen WT, Fuh JL, Lu SR, Wang SJ. Persistent migrainous visual phenomena might be responsive to lamotrigine. Headache 2001; 41: 823-825.
  6. ^ Rozen TD. Treatment of a prolonged migrainous aura with intravenous furosemide. Neurology 2000; 55: 732-733.

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