Persistent aura without infarction

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Persistent aura without infarction
SpecialtyNeurology Edit this on Wikidata

Persistent aura without infarction (PAWOI) is a little-known condition, first described under the designation prolonged migraine aura status,[1] that is not yet fully understood. PAWOI is said to be a possible cause of a variety of neurological symptoms, including visual snow, loss of vision, increased afterimages, tinnitus, and others. However, the pathogenesis of PAWOI is unknown; in other words, it is not known exactly what causes these symptoms. Furthermore, it is not clear which medical examinations are useful in diagnosing PAWOI. At present, PAWOI is usually diagnosed solely based on the patient's present and past symptoms. It may be possible that an overactive brain or a chemical imbalance is partly to blame for the disorder. Different medication has been tried as treatment, notably acetazolamide,[2] valproate,[3] lamotrigine,[4] topiramate, and furosemide.[5]


  1. ^ Haas, David C. (February 1982). "Prolonged migraine aura status". Annals of Neurology. 11 (2): 197–9. doi:10.1002/ana.410110217. PMID 7073253.
  2. ^ Haan, J; Sluis, P; Sluis, LH; Ferrari, MD (28 November 2000). "Acetazolamide treatment for migraine aura status". Neurology. 55 (10): 1588–9. doi:10.1212/WNL.55.10.1588. PMID 11094126.
  3. ^ Rothrock, JF (January 1997). "Successful treatment of persistent migraine aura with divalproex sodium". Neurology. 48 (1): 261–2. doi:10.1212/WNL.48.1.261. PMID 9008529.
  4. ^ Chen, WT; Fuh, JL; Lu, SR; Wang, SJ (September 2001). "Persistent migrainous visual phenomena might be responsive to lamotrigine". Headache. 41 (8): 823–5. doi:10.1046/j.1526-4610.2001.01150.x. PMID 11576209.
  5. ^ Rozen, Todd D. (12 September 2000). "Treatment of a prolonged migrainous aura with intravenous furosemide". Neurology. 55 (5): 732–3. doi:10.1212/WNL.55.5.732. PMID 10980751.