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Pestilence may refer to:

  • Pestilence one of the four Horsemen of the Apocalypse symbolizing Plague (contagious disease) in some interpretations of the book of Revelation
  • Pestilence (band), a Dutch death metal group
  • Pestilence (comics), a Marvel Comics supervillain, based on the biblical horseman
  • "The Pestilence", a song by Kreator from Pleasure to Kill
  • Pestilence wort, a perennial plant native to Europe and northern Asia.
  • Prelude to Pestilence, a scenario in the Realmz fantasy adventure and role-playing video game

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