Peter Hotez

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Peter Hotez
Peter Hotez.jpg
Born
Peter Jay Hotez

(1958-05-05)May 5, 1958
NationalityAmerican
Alma materYale University (B.A.)

Weill Cornell Medical College (M.D.)

Rockefeller University (Ph.D.)
Scientific career
FieldsVaccinology, Neglected Tropical Disease Control, Public Policy, Global Health
InstitutionsGeorge Washington University Medical School, Baylor College of Medicine, Texas Children's Hospital, James Baker Institute

Peter Jay Hotez (born May 5, 1958)[1] is a scientist, pediatrician, and advocate in the fields of global health, vaccinology, and neglected tropical disease control. He serves as founding dean and chief of the Baylor College of Medicine National School of Tropical Medicine in the Department of pediatrics and holds the Texas Children's Hospital Endowed Chair in Tropical Pediatrics.[2]

Early life and education[edit]

Hotez was born in Hartford, Connecticut. He received a BA in Molecular Biophysics and Biochemistry magna cum laude (Phi Beta Kappa) from Yale University in 1980, a PhD from Rockefeller University in 1986, and a Doctorate in Medicine from Weill Cornell Medical College in 1987.[1] His doctoral dissertation and postdoctoral training were in the areas of hookworm molecular pathogenesis and vaccine development.

Research and career[edit]

Early research[edit]

Hotez was awarded postdoctoral positions in molecular parasitology and pediatric infectious diseases at Yale University School of Medicine, where he subsequently became an assistant professor in 1992 and an associate professor in 1995. His early research focused on the pathogenesis and molecular mechanisms of human hookworm infection and would eventually lead to a vaccine now in clinical trials,[3] as well as a vaccine against schistosomiasis, also in clinical trials,[4] either of which would be the first successful vaccine for humans to protect against a multi-cellular parasite.[5]

Neglected tropical diseases (NTDs)[edit]

In 2000-2011, Hotez served as Professor and Chair of the Department of Microbiology and Tropical Medicine (renamed in 2005 as the Department of Microbiology, Immunology, and Tropical Medicine) at the George Washington University.[6]

Following the World Health Organization's (WHO) Millennium Development Goals in 2000, Hotez, along with Drs. Alan Fenwick and David Molyneux, led a global effort to rename diseases then being termed simply "other diseases," as "neglected tropical diseases" (NTDs), and promoting the use of therapeutic/preventive chemotherapy through a combination of drugs called the "rapid-impact package." [7] Hotez has advocated for increased efforts to control NTDs since 2005 through publications and speaking engagements, helping to gain increased awareness resulting in a decrease of prevalence and disease burden in many areas.[8]

During these years, Hotez also led the Sabin Vaccine Institute in Washington, DC, as well as efforts to establish PLOS Neglected Tropical Diseases, the first online open access medical journal focused exclusively on neglected tropical diseases.[9]

Vaccine Development[edit]

In addition to continuing work on vaccines already in clinical trials for hookworm[10] and schistosomiasis[11], Hotez currently leads a team of researchers developing vaccines against other diseases including leishmaniasis, Chagas, SARS, and MERS.[12]

Awards and memberships[edit]

Selected awards and memberships include:

In 2008, he was elected to membership in the Institute of Medicine of the National Academies.[19] He is an ambassador of the Paul G. Rogers Society for Global Health Research, a Fellow of the American Academy of Pediatrics (FAAP), a member of the World Health Organization Scientific and Technical Advisory Committee for WHO TDR (Special Programme on Tropical Diseases Research),[20] and in 2011, Hotez was appointed as a member of the National Institutes of Health (NIH) Council of Councils.[21] He is a member of the inaugural class of Fellows of the American Society of Tropical Medicine and Hygiene.[22]

Publications and media[edit]

Hotez is the author of more than 400 scientific and technical papers on NTDs. In addition he is the author of Blue Marble Health: An Innovative Plan to Fight Diseases of the Poor amid Wealth and Forgotten People, Forgotten Diseases: The Neglected Tropical Diseases and Their Impact on Global Health and Development,[23] co-author of Parasitic Diseases, 5th Edition,[24] a co-editor of Krugman's Infectious Diseases of Children, 11th Edition,[25] and co-editor of Manson's Tropical Diseases, 23rd Edition and Feigin and Cherry's Textbook of Pediatric Infectious Diseases, 7th Edition. In addition, Hotez writes frequently for lay audiences, including papers in Scientific American and op-ed pieces for e.g. the New York Times.

References[edit]

  1. ^ a b Hotez, Peter J. "Curriculum Vitae & Bibliography". Baker Institute. Retrieved 2017-09-18.
  2. ^ "Expert named to lead new tropical disease research center". Houston Chronicle. 2011-06-08. Retrieved 2017-11-17.
  3. ^ Safety and Immunogenicity of a Human Hookworm Candidate Vaccine With or Without Additional Adjuvant in Brazilian Adults, https://clinicaltrials.gov/ct2/show/NCT01261130?term=NCT01261130&rank=1
  4. ^ A Phase I Study of the Safety, Reactogenicity, and Immunogenicity of Sm-TSP-2/Alhydrogel® With or Without GLA-AF for Intestinal Schistosomiasis in Healthy Adults, https://clinicaltrials.gov/ct2/show/NCT02337855
  5. ^ Encyclopedic Reference of Parasitology, Heinz Melhorn Ed. Vaccines against Nematodes.
  6. ^ https://www2.gwu.edu/~bygeorge/feb08/hotez.html
  7. ^ Control of Neglected Tropical Diseases: Integrated Chemotherapy and Beyond, http://researchonline.lshtm.ac.uk/11016/1/pmed.0030112.pdf
  8. ^ Look What Happens When You Pay Attention To Neglected Tropical Diseases, Bruce Y Lee, Forbes 4-24-2017,https://www.forbes.com/sites/brucelee/2017/04/24/look-what-happens-when-you-pay-attention-to-neglected-tropical-diseases/#1c513bba221a
  9. ^ PLOS NTDs celebrates our 10th anniversary: Looking forward to the next decade, http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0006176
  10. ^ Safety and Immunogenicity of a Human Hookworm Candidate Vaccine With or Without Additional Adjuvant in Brazilian Adults, https://clinicaltrials.gov/ct2/show/NCT01261130?term=NCT01261130&rank=1
  11. ^ A Phase I Study of the Safety, Reactogenicity, and Immunogenicity of Sm-TSP-2/Alhydrogel® With or Without GLA-AF for Intestinal Schistosomiasis in Healthy Adults, https://clinicaltrials.gov/ct2/show/NCT02337855
  12. ^ Texas Children's Hospital, https://www.texaschildrens.org/departments/vaccine-development/our-team
  13. ^ https://www.amacad.org/content/members/newFellows.aspx?s=a
  14. ^ http://www.provincia.com.mx/web/Por_d%C3%A9cimo_a%C3%B1o_consecutivo,_se_entregan_los_Premios_Carlos_Slim_en_Salud-72446
  15. ^ "Dean of the National School of Tropical Medicine to Receive B'nai B'rith's Distinguished Achievement Award" (Press release). 2017-03-01. Retrieved 2017-11-17.
  16. ^ http://www.paho.org/blogs/cd51/?p=2937&lang=en
  17. ^ "Bailey K. Ashford Medal". American Society of Tropical Medicine and Hygiene. Retrieved 2017-11-17.
  18. ^ "Archived copy". Archived from the original on June 10, 2010. Retrieved 2010-07-24.
  19. ^ "Peter Hotez". Institute of Medicine. 2014-08-15. Archived from the original on 2010-05-28. Retrieved 2015-05-02.
  20. ^ "WHO | Control of Neglected Tropical Diseases is feasible". World Health Organization. Retrieved 2017-11-17.
  21. ^ "New NIH Council of Councils members named, April 26, 2011 News Release - National Institutes of Health (NIH)". Nih.gov. 2011-04-26. Retrieved 2017-11-17.
  22. ^ "American Society of Tropical Medicine and Hygiene : ASTMH Names Peter Hotez as New President". Astmh.org. November 7, 2010. Archived from the original on May 11, 2015. Retrieved 2015-05-02.
  23. ^ "Forgotten People, Forgotten Diseases: The Neglected Tropical Diseases and Their Impact on Global Health and Development: 9781555814403: Medicine & Health Science Books @". ASM Press. Retrieved 2017-11-17.
  24. ^ "Parasitic Diseases, Fifth Edition: 9780970002778: Medicine & Health Science Books @". Amazon.com. Retrieved 2017-11-17.
  25. ^ Arvin Ann (2004) [1998]. "Krugman's Infectious Diseases of Children". The New England Journal of Medicine (10th/11th ed.). Elsevier Health Sciences. 338: 785. doi:10.1056/NEJM199805213382119. ISBN 0-8151-5251-5. OL 687625M.

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