Peter Keightley

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Peter Keightley
Professor Peter Keightley FRS.jpg
Peter Keightley at the Royal Society admissions day in London, July 2014
Peter D. Keightley
Alma materUniversity of Edinburgh (PhD)
AwardsFRS (2014)[1]
Scientific career
InstitutionsUniversity of Edinburgh
ThesisStudies of quantitative genetic variation (1989)
Doctoral advisorWilliam G. Hill

Peter D. Keightley FRS[1] is Professor of Evolutionary Genetics at the Institute of Evolutionary Biology in School of Biological Sciences at the University of Edinburgh.[2][3]


Keightley was educated at the University of Edinburgh where he was awarded a PhD in 1989 for research on genetic variation[4] supervised by William G. Hill.[4]


Keightley leads a laboratory which works on evolutionary genetics and the evolutionary impact of new mutations on molecular genetic and quantitative trait variation and fitness. His research investitages genetic variation and adaptation through the analysis of nucleotide variation within natural populations and between different species.[5][6][7][8][9][10][11][12]

Keightley's research has been funded by the Biotechnology and Biological Sciences Research Council (BBSRC).[13]

Awards and honours[edit]

Keightley was elected a Fellow of the Royal Society in 2014. His nomination reads:

Personal life[edit]

Keightley's uncle (Mike Keightley) was involved in the investigation of the Boston Strangler.[citation needed]


  1. ^ a b c Anon (2014). "Professor Peter Keightley FRS". London: Royal Society.
  2. ^ List of publications from Microsoft Academic[dead link]
  3. ^ Peter Keightley publications indexed by the Scopus bibliographic database. (subscription required)
  4. ^ a b Keightley, Peter (1988). Studies of quantitative genetic variation (PhD thesis). University of Edinburgh. hdl:1842/12340. open access
  5. ^ Drosophila 12 Genomes, Consortium; Clark, A. G.; Eisen, M. B.; Smith, D. R.; Bergman, C. M.; Oliver, B; Markow, T. A.; Kaufman, T. C.; Kellis, M; Gelbart, W; Iyer, V. N.; Pollard, D. A.; Sackton, T. B.; Larracuente, A. M.; Singh, N. D.; Abad, J. P.; Abt, D. N.; Adryan, B; Aguade, M; Akashi, H; Anderson, W. W.; Aquadro, C. F.; Ardell, D. H.; Arguello, R; Artieri, C. G.; Barbash, D. A.; Barker, D; Barsanti, P; Batterham, P; et al. (2007). "Evolution of genes and genomes on the Drosophila phylogeny". Nature. 450 (7167): 203–18. doi:10.1038/nature06341. PMID 17994087.
  6. ^ Barton, N. H.; Keightley, P. D. (2002). "Understanding quantitative genetic variation". Nature Reviews Genetics. 3 (1): 11–21. doi:10.1038/nrg700. PMID 11823787.
  7. ^ Eyre-Walker, A.; Keightley, P. (August 2007). "The distribution of fitness effects of new mutations". Nature Reviews Genetics. 8 (8): 610–618. doi:10.1038/nrg2146. ISSN 1471-0056. PMID 17637733.
  8. ^ Eyre-Walker, A; Keightley, P. D. (1999). "High genomic deleterious mutation rates in hominids". Nature. 397 (6717): 344–7. doi:10.1038/16915. PMID 9950425.
  9. ^ Millar, C. B.; Guy, J; Sansom, O. J.; Selfridge, J; MacDougall, E; Hendrich, B; Keightley, P. D.; Bishop, S. M.; Clarke, A. R.; Bird, A (2002). "Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice". Science. 297 (5580): 403–5. doi:10.1126/science.1073354. PMID 12130785.
  10. ^ Haag-Liautard, C; Dorris, M; Maside, X; MacAskill, S; Halligan, D. L.; Houle, D; Charlesworth, B; Keightley, P. D. (2007). "Direct estimation of per nucleotide and genomic deleterious mutation rates in Drosophila". Nature. 445 (7123): 82–5. doi:10.1038/nature05388. PMID 17203060.
  11. ^ Keightley, P. D. (1994). "The distribution of mutation effects on viability in Drosophila melanogaster". Genetics. 138 (4): 1315–22. PMC 1206267. PMID 7896110.
  12. ^ Keightley, Peter D.; Otto, Sarah P. (2006). "Interference among deleterious mutations favours sex and recombination in finite populations". Nature. 443 (7107): 89–92. doi:10.1038/nature05049. PMID 16957730.
  13. ^ UK Government research grants awarded to Peter Keightley, via Research Councils UK