His first full-length novel Rivers of Babylon was published in 1991 (in English in 2007 in a translation by Peter Petro). It was followed by two other novels, The Wooden Village and The End of Freddy, which together make up a trilogy. They recount the life of Rácz, a fictitious gangster who emerged in autumn 1989 as communist rule was disintegrating. Pišťanek was also an active writer about the alcohol beverage industry, providing his insight and humour on both spirits and wines including cognac and bourbon.
On 22 March 2015, Pišťanek committed suicide.