Letang grew up in east London, and attended the Anna Scher Theatre school in Islington, London. She has played Donna Lewis in the Channel 5 soap Family Affairs in 1999, and the character Pauline in the BBC2 drama Babyfather in 2002. Other television credits have included Jonathan Creek (2004), The Bill (2005) and The Last Detective (2005). She also appeared in the British film Wondrous Oblivion in 2003.
In 2005, Letang was cast as Naomi Julien — the lesbian lover of Sonia Fowler (Natalie Cassidy) — in BBC's EastEnders. She left the role in 2007, reportedly because scriptwriters had "run out of ideas for her". Prior to this, Letang had gone public with her fears that her character would be axed following a "bad public reaction" to the lesbian storyline that saw Naomi break up the marriage of Sonia and Martin Fowler (James Alexandrou).
In March 2007, Letang was one of several television stars who took part in Searchlight magazine's "Hope Not Hate bus" campaign with the Daily Mirror, which was aimed at spreading a message of goodwill in the build-up to the local elections in May 2007. Letang commented: "This campaign is very close to my heart. We have to make a difference for the young people coming up."
Letang starred in Jason Barrett's film The Naked Poet in 2011, in which she played the lead female role Simone and gave what was described as a "stand out performance". She was also credited as both producer and one of the executive producers.
Letang began starring in Holby City on 14 January 2014. As Adele Effanga, younger sister of Mo Effanga (Chizzy Akudolu). She is cast as the shows first regular healthcare assistant working alongside her sister on the same ward.
- Family Affairs - Donna Lewis (1999)
- Wondrous Oblivion - Loretta (2003)
- EastEnders - Naomi Julien (2005–2007)
- The Naked Poet - Simone (2011)
- Holby City - Adele Effanga (2014–2016)
- Nicola Methven And Polly Hudson (2007-01-19). "LETANGOED!". The Mirror. Retrieved 2007-09-10.
- "NAOMI'S AXE FEAR". The Mirror. 2006-04-24. Retrieved 2007-09-10.
- "'ANGIE LE MAR: FUNNY BLACK WOMEN ON THE EDGE'". blacknet.co.uk. Retrieved 2007-09-10.
- "LIFE AFTER ENDERS FOR PETRA". The Mirror. Retrieved 2007-09-10.
- "BILL ABOARD!". The Mirror. Retrieved 2007-09-10.
- Scene Profiles| The Naked Poet – a Film by Jason Barrett, Scene TV.