Pexelizumab

Pexelizumab
Monoclonal antibody
Type	Single-chain variable fragment
Source	Humanized (from mouse)
Target	Complement component 5
Clinical data
ATC code	none;
Legal status
Legal status	investigational;
Identifiers
ChemSpider	none;
UNII	CHZ6OLQ3UU;
KEGG	D10023 ;
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Pexelizumab is a drug designed to reduce side effects of coronary artery bypass grafting^[1] and angioplasty,^[2]^[3] among other types of cardiac surgery. It is a single chain variable fragment of a monoclonal antibody targeted against component 5 of the complement system.^[4]

Current status[edit]

Alexion, the developer of pexelizumab, stopped development when the phase 3 trial indicated the heart-attack drug is no better than placebo.^[5]

^ ClinicalTrials.gov: Pexelizumab in Patients Undergoing Coronary Artery Bypass Grafting With Cardiopulmonary Bypass
^ ClinicalTrials.gov: Pexelizumab in Conjunction With Angioplasty in Acute Myocardial Infarction
^ Testa, L; Van Gaal, WJ; Bhindi, R; Biondi-Zoccai, GG; Abbate, A; Agostoni, P; Porto, I; Andreotti, F; et al. (2008). "Pexelizumab in ischemic heart disease: a systematic review and meta-analysis on 15,196 patients". The Journal of Thoracic and Cardiovascular Surgery. 136 (4): 884–93. doi:10.1016/j.jtcvs.2007.12.062. PMID 18954626.
^ Mathew, JP; Shernan, SK; White, WD; Fitch, JC; Chen, JC; Bell, L; Newman, MF (2004). "Preliminary report of the effects of complement suppression with pexelizumab on neurocognitive decline after coronary artery bypass graft surgery". Stroke: A Journal of Cerebral Circulation. 35 (10): 2335–9. doi:10.1161/01.STR.0000141938.00524.83. PMID 15331798.
^ [1] Analysis: Alexion's pexelizumab fails

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