Phenaridine

From Wikipedia, the free encyclopedia
Jump to: navigation, search
Phenaridine
Phenaridine.svg
Clinical data
ATC code
  • none
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
Formula C24H32N2O
Molar mass 364.52 g/mol
3D model (Jmol)
 NYesY (what is this?)  (verify)

Phenaridine (2,5-Dimethylfentanyl) is an opioid analgesic that is an analogue of fentanyl. It was developed in 1972,[1] and is used for surgical anasthesia.[2][3]

Phenaridine has similar effects to fentanyl. It is slightly less potent than fentanyl in rats.[1] Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea and potentially serious respiratory depression, which can be life-threatening. Fentanyl analogs have killed hundreds of people throughout Europe and the former Soviet republics since the most recent resurgence in use began in Estonia in the early 2000s, and novel derivatives continue to appear.[4]

See also[edit]

References[edit]

  1. ^ a b Riley NT, Hale DB, Wilson MV. 4-Anilidopiperidine Analgesics I: Synthesis and Analgesic Activity of Certain Ring-Methylated 1-Substituted 4-Propananilidopiperidines. J. Pharm. Sci 62(6): 983 (1973)
  2. ^ Osipova NA, Petrova VV, Novikov GA, Dolgopolova TV, Zhukova OI, Mel'nikova ZL, Smolina TA. The new Soviet narcotic analgesic phenaridine as a component of general anesthesia during cancer surgery. (Russian). Anesteziologiia i Reanimatologiia. 1991 Jan-Feb;(1):42-6.
  3. ^ Vlasenko EV, Durgarian LK, Azlivian AS, Sarukhanian KV. The evaluation of the analgesic action of phenaridine when combined with agents used in anesthesiological practice. (Russian). Farmakologiia i Toksikologiia. 1991 May-Jun;54(3):17-20.
  4. ^ Jane Mounteney, Isabelle Giraudon, Gleb Denissov, Paul Griffiths (July 2015). "Fentanyls: Are we missing the signs? Highly potent and on the rise in Europe.". The international journal of drug policy. 26 (7): 626–631. doi:10.1016/j.drugpo.2015.04.003. PMID 25976511.