Phenethyl isothiocyanate

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Phenethyl isothiocyanate
Phenethyl isothiocyanate.svg
Phenethyl isothiocyanate-3D-balls-by-AHRLS-2012.png
Phenethyl isothiocyanate-3D-vdW-by-AHRLS-2012.png
Names
IUPAC name
(2-Isothiocyanatoethyl)benzene
Other names
Phenylethyl isothiocyanate; Phenethyl mustard oil
Identifiers
3D model (JSmol)
Abbreviations PEITC
ChEBI
ChemSpider
ECHA InfoCard 100.017.142
UNII
Properties
C9H9NS
Molar mass 163.24 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Phenethyl isothiocyanate (PEITC) is a naturally occurring isothiocyanate whose precursor, gluconasturtiin is found in some cruciferous vegetables,[1] especially watercress.

PEITC has been studied for its potential for chemoprevention of cancers,[2][3] such as prostate cancer.[4]

In terms of biosynthesis, PEITC is produced from gluconasturtiin by the action of the enzyme myrosinase.

References[edit]

  1. ^ "Dictionary of Cancer Terms: PEITC". National Cancer Institute. 
  2. ^ Cheung, KL; Kong, AN (2010). "Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention". The AAPS Journal. 12 (1): 87–97. PMC 2811646Freely accessible. PMID 20013083. doi:10.1208/s12248-009-9162-8. 
  3. ^ Kwon, Ki Han; Xu, Changjiang; Keum, Young-Sam; Khor, Tin Oo; Kim, Jung-Hwan; Huang, Mou-Tuan; Reddy, Bandaru S.; Li, Wenge; Kong, Ah-Ng Tony (2007). "Natural dietary phytochemicals: a promising future for cancer prevention and treatment of earlier lesion". Cancer: Disease Progression and Chemoprevention: 109–126. 
  4. ^ Wang, LG; Chiao, JW (2010). "Prostate cancer chemopreventive activity of phenethyl isothiocyanate through epigenetic regulation (review)". International Journal of Oncology. 37 (3): 533–9. PMID 20664922. doi:10.3892/ijo_00000702.