|AHFS/Drugs.com||International Drug Names|
|Elimination half-life||5 - 8 hours|
|Chemical and physical data|
|Molar mass||179.22 g·mol−1|
|3D model (JSmol)|
|(what is this?)|
Phenprobamate (Gamaquil, Isotonil) is a centrally acting skeletal muscle relaxant, with additional sedative and anticonvulsant effects. Overdose is similar to barbiturates. Its mechanism of action is probably similar to meprobamate. Phenprobamate has been used in humans as an anxiolytic, and is still sometimes used in general anesthesia and for treating muscle cramps and spasticity. Phenprobamate is still used in some European countries, but it has generally been replaced by newer drugs. Phenprobamate is metabolized by oxidative degradation of the carbamate group and ortho-hydroxylation of the benzene ring, and is eliminated in urine by the kidneys.
Doses range from 400 to 800 mg, up to 3 times a day.
This article includes a list of references, related reading or external links, but its sources remain unclear because it lacks inline citations. (June 2011) (Learn how and when to remove this template message)
- The Comparative Toxicogenomics Database: Phenprobamate
- Chembank: Phenprobamate
- Nephrology Dialysis Transplantation Volume 17, Number 5, Pp. 941. Letters: Haemoperfusion may be useful in phenprobamate and polypharmacy intoxication of paediatric patients.
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