Phenylalanine(histidine) transaminase

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phenylalanine(histidine) transaminase
Identifiers
EC number 2.6.1.58
CAS number 72560-98-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a phenylalanine(histidine) transaminase (EC 2.6.1.58) is an enzyme that catalyzes the chemical reaction

L-phenylalanine + pyruvate phenylpyruvate + L-alanine

Thus, the two substrates of this enzyme are L-phenylalanine and pyruvate, whereas its two products are phenylpyruvate and L-alanine.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-phenylalanine:pyruvate aminotransferase. Other names in common use include phenylalanine (histidine) aminotransferase, phenylalanine(histidine):pyruvate aminotransferase, histidine:pyruvate aminotransferase, and L-phenylalanine(L-histidine):pyruvate aminotransferase.

References[edit]

  • Minatogawa Y, Noguchi T, Kido R (1977). "Species distribution and properties of hepatic phenylalanine (histidine):pyruvate aminotransferase". Hoppe. Seylers. Z. Physiol. Chem. 358 (1): 59–67. PMID 14070. doi:10.1515/bchm2.1977.358.1.59.